Reactome | iRHOM2 [Golgi lumen]

iRHOM2 [Golgi lumen]

Stable Identifier

R-HSA-9673787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)
        
        iRHOM2 [Golgi lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6PJF5 RHBDF2

Gene Names

RHBDF2, IRHOM2, RHBDL5, RHBDL6

Chain

chain:1-856

Reference Genes

BioGPS Gene:79651 RHBDF2

COSMIC (genes):RHBDF2 RHBDF2

CTD Gene:79651 RHBDF2

dbSNP Gene:79651 RHBDF2

ENSEMBL:ENSG00000129667 RHBDF2

ENSEMBL_homo_sapiens_GENE:ENSG00000129667.13 RHBDF2

HGNC:20788 RHBDF2

KEGG Gene (Homo sapiens):79651 RHBDF2

Monarch:79651 RHBDF2

NCBI Gene:79651 RHBDF2

OMIM:614404 RHBDF2

UCSC:Q6PJF5 RHBDF2

Reference Transcript

Other Identifiers

11739795_a_at

11739796_a_at

11749501_a_at

16849238

219202_PM_at

219202_at

3771603

3771604

3771606

3771608

3771609

3771610

3771611

3771612

3771614

3771615

3771616

3771618

3771619

3771621

3771622

3771623

3771624

3771626

3771628

3771629

3771630

3771634

3771640

3771641

50427_at

79651

8018731

GE56928

GO:0002376

GO:0002862

GO:0003824

GO:0004252

GO:0005215

GO:0005515

GO:0005783

GO:0005789

GO:0005794

GO:0005796

GO:0005886

GO:0006954

GO:0015031

GO:0016020

GO:0016787

GO:0019838

GO:0023052

GO:0042058

GO:0043226

GO:0050708

GO:0050709

GO:0072659

GO:0140096

GO:0140318

HMNXSV003056795

ILMN_1691717

ILMN_1735792

ILMN_2373062

PH_hs_0002241

TC17001899.hg

g13375798_3p_at

Other forms of this molecule

iRHOM2 [endoplasmic reticulum membrane]

Cross References

RefSeq

XP_011523551.1, XP_011523552.1, XP_005257726.1, XP_011523553.1, NP_078875.4, XP_016880568.1, XP_005257727.1, NP_001005498.2

OpenTargets

ENSG00000129667

HPA

ENSG00000129667-RHBDF2

GeneCards

Q6PJF5

Ensembl

ENST00000675367, ENSP00000466867, ENSG00000129667, ENSP00000501790, ENST00000591885, ENSP00000322775, ENST00000313080

PRO

Q6PJF5

Pharos - Targets

Q6PJF5

HMDB Protein

HMDBP13414

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.527	2

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