Reactome | KIF23 [cytosol]

KIF23 [cytosol]

Stable Identifier

R-HSA-1015863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKLP1, Kinesin-like protein KIF23

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02241 KIF23

Gene Names

KIF23, KNSL5, MKLP1

Chain

chain:1-960

Reference Genes

BioGPS Gene:9493 KIF23

COSMIC (genes):KIF23 KIF23

CTD Gene:9493 KIF23

dbSNP Gene:9493 KIF23

ENSEMBL:ENSG00000137807 KIF23

ENSEMBL:ENSG00000137807.16 KIF23

HGNC:6392 KIF23

KEGG Gene (Homo sapiens):9493 KIF23

Monarch:9493 KIF23

NCBI Gene:9493 KIF23

OMIM:605064 KIF23

UCSC:Q02241 KIF23

Reference Transcript

Other Identifiers

11721932_a_at

11756918_a_at

16802519

204709_PM_s_at

204709_s_at

3599812

3599813

3599815

3599816

3599817

3599818

3599820

3599823

3599825

3599826

3599828

3599829

3599830

3599831

3599832

3599833

3599836

3599837

3599838

3599839

3599843

3599845

3599848

3599851

3599852

3599853

37171_at

7984540

9493

A_14_P119304

A_14_P128503

A_23_P48835

A_33_P3311755

GE62342

GO:0000022

GO:0000166

GO:0000278

GO:0000281

GO:0000910

GO:0003774

GO:0003777

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005925

GO:0007010

GO:0007018

GO:0007049

GO:0007059

GO:0008017

GO:0008092

GO:0016787

GO:0016887

GO:0030496

GO:0032467

GO:0043226

GO:0051256

GO:0051301

GO:0072686

GO:0090543

GO:0097149

GO:0140014

GO:0140657

HMNXSV003015069

HMNXSV003041155

ILMN_1716553

ILMN_1811472

PH_hs_0013935

TC15000638.hg

X67155_at

g13699831_3p_a_at

Participates

as a member of

Kinesin-6 [cytosol] (Homo sapiens)

Other forms of this molecule

KIF23 [nucleoplasm]

p-S911,S912-KIF23 [nucleoplasm]

Inferred To

KIF23 [cytosol] (Bos taurus)

KIF23 [cytosol] (Caenorhabditis elegans)

KIF23 [cytosol] (Canis familiaris)

KIF23 [cytosol] (Danio rerio)

KIF23 [cytosol] (Drosophila melanogaster)

KIF23 [cytosol] (Gallus gallus)

KIF23 [cytosol] (Mus musculus)

KIF23 [cytosol] (Rattus norvegicus)

KIF23 [cytosol] (Sus scrofa)

KIF23 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004847.2, NP_612565.1

OpenTargets

ENSG00000137807

HPA

ENSG00000137807-KIF23

GeneCards

Q02241

ZINC target

Q02241

Ensembl

ENSG00000137807, ENSP00000497065, ENST00000260363, ENST00000352331, ENSP00000260363, ENST00000647715, ENSP00000304978

PRO

Q02241

Pharos - Targets

Q02241

Orphanet

22229

PDB

3VHX

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.836	6
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.816	12
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.813	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	3
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.667	23
UniProt:P62331	2	ARF6 [cytosol] (R-MMU-8871121) ARF6 [recycling endosome membrane] (R-MMU-2029049)	0.66	10
UniProt:Q7RTP6-1 MICAL3			0.576	8
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.564	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.564	2
UniProt:Q9JLQ0 Cd2ap	1	CD2AP_MOUSE [cytosol] (R-MMU-451711)	0.564	2
UniProt:Q9Z179 SHCBP			0.564	2
UniProt:Q9WVM1	1	Racgap1 [cytosol] (R-MMU-195122)	0.564	2
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.556	4
UniProt:Q7RTP6 MICA3			0.491	2