p-S237-TBC1D1 [cytosol]

Stable Identifier
R-HSA-1454673
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TBC1D1 (pSer237), TBC1 domain family member 1, TBCD1_HUMAN, TBC1D1
Locations in the PathwayBrowser
Expand all
General
As inferred from rat L6 muscle cells, TBC1D1 is located in the perinuclear cytosol (Chen et al. 2008). TBC1D1 is observed throughout the cytosol and, based on its homology to TBC1D4 and its interaction with membrane-bound RAB proteins, TBC1D1 is expected to be concentrated near vesicle membranes.
Literature References
PubMed ID Title Journal Year
20701589 Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

An, D, Hirshman, MF, Goodyear, LJ, Vichaiwong, K, Jessen, N, Purohit, S, Toyoda, T

Biochem J 2010
17995453 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Campbell, DG, Murphy, J, Toth, R, Chen, S, Morrice, NA, Mackintosh, C

Biochem J 2008
External Reference Information
External Reference
UniProt:Q86TI0 TBC1D1
Gene Names
TBC1D1, KIAA1108
Chain
chain:1-1168
Reference Genes
BioGPS Gene:23216 TBC1D1
COSMIC (genes):TBC1D1 TBC1D1
CTD Gene:23216 TBC1D1
dbSNP Gene:23216 TBC1D1
ENSEMBL:ENSG00000065882 TBC1D1
ENSEMBL_homo_sapiens_GENE:ENSG00000065882.18 TBC1D1
HGNC:11578 TBC1D1
KEGG Gene (Homo sapiens):23216 TBC1D1
Monarch:23216 TBC1D1
NCBI Gene:23216 TBC1D1
OMIM:609850 TBC1D1
UCSC:Q86TI0 TBC1D1
Reference Transcript
Other Identifiers
11720224_a_at
11720225_a_at
11720226_s_at
11747994_a_at
11747995_x_at
11752285_a_at
1568713_3p_a_at
1568713_PM_a_at
1568713_a_at
16965942
212350_PM_at
212350_at
227945_PM_at
227945_at
23216
2723758
2723759
2723760
2723769
2723770
2723771
2723807
2723808
2723809
2723814
2723816
2723818
2723824
2723827
2723831
2723832
2723833
2723834
2723835
2723837
2723839
2723860
2723869
2723872
2723885
2723886
2723887
2723889
2723897
2723913
2723920
2723921
2723922
2723923
32506_at
44004_at
79917_at
8094574
A_14_P132551
A_14_P201721
A_23_P73023
A_24_P943613
GE62774
GO:0005096
GO:0005515
GO:0005634
GO:0043226
GO:0098772
HMNXSV003052187
Hs.27356.0.A1_3p_at
Hs.278586.1.A1_3p_at
Hs2.203722.1.A1_3p_a_at
Hs2.203722.1.A1_3p_s_at
Hs2.203722.1.A1_3p_x_at
ILMN_1754947
PH_hs_0024215
PH_hs_0032943
TC04000214.hg
Participates
as a component of
as an output of
as an input of
Other forms of this molecule
TBC1D1 [cytoplasmic vesicle membrane]
Modified Residues
Name
O-phospho-L-serine at 237
Coordinate
237
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (32)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.816 7
 UniProt:Q04917 YWHAH  1 0.802 7
 UniProt:P63104 YWHAZ  2 0.745 5
 UniProt:P31946 YWHAB  1 0.745 6
 UniProt:P27348 YWHAQ  1 0.671 6
 UniProt:Q8NEU8 DP13B      0.576 4
 UniProt:P62258 YWHAE  1 0.569 4
 UniProt:O75031 HSF2B      0.556 3
 UniProt:Q96JM7-2 L3MBTL3      0.556 3
 UniProt:Q9Y250 LZTS1      0.556 3
 UniProt:Q3B820 F161A      0.556 3
 UniProt:Q2TBE0 CWF19L2  1 0.556 3
 UniProt:Q15560 TCEA2      0.556 3
 UniProt:Q8N1B4 VPS52  1 0.556 3
 UniProt:Q68G74 LHX8      0.556 3
 UniProt:Q96C24 SYTL4  2 0.556 3
 IntAct:EBI-16882364 CALM1      0.556 3
 UniProt:Q13671 RIN1  1 0.556 3
 UniProt:Q9Y247 FA50B      0.556 3
 UniProt:Q8N715 CC185      0.556 3
 UniProt:P31273 HOXC8  1 0.556 3
 UniProt:Q96IK5 GMCL1      0.556 3
 UniProt:P40222 TXLNA  1 0.556 3
 UniProt:Q6P2D0 ZFP1  1 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:P02585 TNNC2  1 0.556 3
 UniProt:Q5JST6 EFHC2      0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:Q3SY00 T10IP      0.556 3
 UniProt:O95678 KRT75  1 0.556 3
 UniProt:Q8TBB1 LNX1  1 0.556 3
 UniProt:O60293 ZC3H1      0.527 2
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