Reactome | ywhah [cytosol]

ywhah [cytosol]

Stable Identifier

R-DRE-1445107

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

YWHAH, Q7T3G2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - G2/M Checkpoints (Danio rerio)
    - G2/M DNA damage checkpoint (Danio rerio)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Danio rerio)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Metabolic Genes (Danio rerio)
        
        DDIT4 binds 14-3-3 dimer (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        DDIT4:14-3-3 dimer [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)

Programmed Cell Death (Danio rerio)

- Apoptosis (Danio rerio)
  - Intrinsic Pathway for Apoptosis (Danio rerio)
    - Activation of BH3-only proteins (Danio rerio)
      - Activation of BAD and translocation to mitochondria (Danio rerio)
        
        Activation of BAD by calcineurin (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        Sequestration of BAD protein by 14-3-3 (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases activate PKNs (Danio rerio)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        YWHAH dimer [cytosol] (Danio rerio)
        
        ywhah [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T3G2

Gene Names

ywhah

Reference Genes

BioGPS Gene:406443 ywhah

ENSEMBL:ENSDARG00000005560

KEGG:dre:406443 ywhah

Monarch:406443 ywhah

NCBI Gene:406443 ywhah

UCSC:Q7T3G2 ywhah

Reference Transcript

RefSeq:NM_213164.2 ywhah

Other Identifiers

12962196

406443

A_15_P110484

A_15_P111374

CJ012422

CJ014443

CUST_2299_PI428451958

DRER02533

Dr.1524.1.S1_at

ENSDART00000020122

ENSDART00000020122_1

ENSDART00000020122_2

GT_Spec_NM_213164.2_331705

LOL00267

LOL01267

LOL03608

LOL03609

LOL03611

LOL03612

LOL03613

LOL03614

LOL03615

LOL05110

LOLS01330

MADDr01008815

NM_213164

OTTDART00000028374

Participates

as a component of

YWHAH dimer [cytosol] (Danio rerio)

Inferred From

YWHAH [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998329.1

ENSEMBL

ENSDART00000020122, ENSDARG00000005560, ENSDARP00000008690

ZFIN

ZDB-GENE-040426-2191