Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDC25B [cytosol]
Stable Identifier
R-HSA-157412
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cdc25B, M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B), M-phase inducer phosphatase 2 , Dual specificity phosphatase Cdc25B
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
CDC25B [cytosol] (Homo sapiens)
Translocation of Cdc25 to the nucleus (Homo sapiens)
CDC25 [cytosol] (Homo sapiens)
CDC25B [cytosol] (Homo sapiens)
Translocation of Cdc25B to the cytoplasm (Homo sapiens)
CDC25B [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)
CDC25B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30305 CDC25B
Gene Names
CDC25B, CDC25HU2
Chain
chain:1-580
Reference Genes
BioGPS Gene:994 CDC25B
COSMIC (genes):CDC25B CDC25B
CTD Gene:994 CDC25B
dbSNP Gene:994 CDC25B
ENSEMBL:ENSG00000101224 CDC25B
HGNC:1726 CDC25B
KEGG:hsa:994 CDC25B
Monarch:994 CDC25B
NCBI Gene:994 CDC25B
OMIM:116949 CDC25B
UCSC:P30305 CDC25B
Reference Transcript
RefSeq:NM_001287519.1 CDC25B
RefSeq:NM_021872.3 CDC25B
RefSeq:NM_021873.3 CDC25B
RefSeq:NM_001287524.1 CDC25B
RefSeq:NM_004358.4 CDC25B
Other Identifiers
11718005_a_at
11747652_a_at
11747653_x_at
11748972_a_at
11748973_x_at
1347_at
16911040
201853_PM_s_at
201853_s_at
3874439
3874441
3874443
3874444
3874446
3874447
3874448
3874452
3874453
3874454
3874455
3874456
3874457
3874458
3874459
3874460
3874461
3874462
3874463
3874464
3874465
3874466
3874467
3874468
3874469
3874471
3874472
3874473
3874474
3874475
8060675
994
A_14_P107596
A_23_P210726
GE62023
GO:0000086
GO:0000278
GO:0000922
GO:0001556
GO:0003824
GO:0004721
GO:0004725
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006468
GO:0006470
GO:0007144
GO:0008284
GO:0010971
GO:0016787
GO:0019901
GO:0022414
GO:0032467
GO:0043226
GO:0045931
GO:0051301
GO:0110032
GO:0140013
GO:0140096
GO:1902751
HMNXSV003020948
ILMN_1740384
ILMN_2338323
PH_hs_0009248
S78187_at
TC20000040.hg
g11641412_3p_s_at
Participates
as an input of
p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)
as an output of
Translocation of Cdc25B to the cytoplasm (Homo sapiens)
as a member of
CDC25 [cytosol] (Homo sapiens)
Other forms of this molecule
CDC25B [nucleoplasm]
p-S50,T69,S160,S321,S470-CDC25B [cytosol]
Inferred To
cdc-25.4 [cytosol]
(Caenorhabditis elegans)
cdc25 [cytosol]
(Dictyostelium discoideum)
cdc25 [cytosol]
(Schizosaccharomyces pombe)
twe [cytosol]
(Drosophila melanogaster)
cdc-25.3 [cytosol]
(Caenorhabditis elegans)
stg [cytosol]
(Drosophila melanogaster)
MIH1 [cytosol]
(Saccharomyces cerevisiae)
cdc-25.1 [cytosol]
(Caenorhabditis elegans)
CDC25B [cytosol]
(Bos taurus)
CDC25B [cytosol]
(Canis familiaris)
CDC25B [cytosol]
(Gallus gallus)
CDC25B [cytosol]
(Sus scrofa)
Cdc25b [cytosol]
(Mus musculus)
Cdc25b [cytosol]
(Rattus norvegicus)
cdc25b [cytosol]
(Xenopus tropicalis)
Homologues of CDC25B [cytosol]
(Caenorhabditis elegans)
Homologues of CDC25B [cytosol]
(Drosophila melanogaster)
cdc-25.2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001274453.1
,
NP_068658.1
,
NP_004349.1
,
NP_068659.1
,
NP_001274448.1
ZINC - World Drugs
MPIP2_HUMAN
OpenTargets
ENSG00000101224
ENSEMBL
ENST00000340833
,
ENST00000439880
,
ENSP00000245960
,
ENSP00000339170
,
ENSP00000405972
,
ENST00000245960
ZINC - Substances
MPIP2_HUMAN
ZINC - Biogenic
MPIP2_HUMAN
ZINC target
P30305
PRO
P30305
GlyGen
P30305
PDB
1YML
,
1YS0
,
1YMK
,
2IFV
,
1YMD
,
1CWT
,
1CWS
,
2UZQ
,
1QB0
,
1CWR
,
3FQT
,
3FQU
,
2A2K
,
4WH9
,
4WH7
,
2IFD
,
1YM9
ZINC - Investigational
MPIP2_HUMAN
ZINC - Metabolites
MPIP2_HUMAN
HPA
ENSG00000101224-CDC25B
Pharos - Targets
P30305
ZINC - Predictions - Purchasable
MPIP2_HUMAN
HMDB Protein
HMDBP08920
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.937
12
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.894
8
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.869
8
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.788
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.763
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.688
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.643
3
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.556
3
UniProt:Q9UKB1-2 FBXW11
0.527
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.527
3
UniProt:P31946-2 YWHAB
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text