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p-S939,T1462-TSC2 [cytosol]
Stable Identifier
R-HSA-199484
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-TSC2
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Homo sapiens)
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49815 TSC2
Gene Names
TSC2, TSC4
Chain
chain:1-1807
Reference Genes
BioGPS Gene:7249 TSC2
COSMIC (genes):TSC2 TSC2
CTD Gene:7249 TSC2
dbSNP Gene:7249 TSC2
ENSEMBL:ENSG00000103197 TSC2
ENSEMBL_homo_sapiens_GENE:ENSG00000103197.19 TSC2
HGNC:12363 TSC2
KEGG Gene (Homo sapiens):7249 TSC2
Monarch:7249 TSC2
NCBI Gene:7249 TSC2
OMIM:191092 TSC2
UCSC:P49815 TSC2
Reference Transcript
RefSeq:NM_001077183.2 TSC2
RefSeq:NM_001318829.1 TSC2
RefSeq:NM_001318832.1 TSC2
RefSeq:XM_017023616.1 TSC2
RefSeq:NM_001318827.1 TSC2
RefSeq:NM_000548.4 TSC2
RefSeq:NM_001318831.1 TSC2
RefSeq:XM_005255529.4 TSC2
RefSeq:NM_001114382.2 TSC2
Other Identifiers
11756886_a_at
16814927
215735_PM_s_at
215735_s_at
3644378
3644379
3644380
3644381
3644382
3644383
3644384
3644387
3644389
3644391
3644392
3644393
3644394
3644395
3644397
3644399
3644401
3644403
3644405
3644407
3644411
3644414
3644416
3644417
3644420
3644426
3644430
3644432
3644433
3644438
3644440
3644441
3644442
3644443
3644444
3644445
3644448
3644450
3644451
3644453
3644455
3644456
3644457
3644458
3644461
3644463
3644465
3644467
3644468
3644469
38813_at
7249
7992474
A_23_P66110
A_33_P3281686
GE60002
GO:0001843
GO:0005096
GO:0005515
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005794
GO:0005829
GO:0006469
GO:0006606
GO:0006886
GO:0006897
GO:0006913
GO:0006914
GO:0007005
GO:0007507
GO:0008104
GO:0008285
GO:0009267
GO:0012501
GO:0014069
GO:0016020
GO:0016192
GO:0016239
GO:0019902
GO:0023052
GO:0030100
GO:0030178
GO:0031267
GO:0032007
GO:0033596
GO:0036211
GO:0042803
GO:0043226
GO:0043276
GO:0043491
GO:0043547
GO:0046626
GO:0046627
GO:0048009
GO:0048471
GO:0048856
GO:0050918
GO:0051056
GO:0051726
GO:0051879
GO:0051898
GO:0098772
GO:1901525
GO:1904262
HMNXSV003008288
ILMN_1762631
L48546_at
PH_hs_0005043
TC16000059.hg
Participates
as an output of
AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
as a component of
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Homo sapiens)
as an input of
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)
Other forms of this molecule
p-S939,S1130,T1462-TSC2 [cytosol]
TSC2 [cytosol]
p-S1387-TSC2 [cytosol]
Inferred To
phospho-Tsc2 [cytosol]
(Mus musculus)
phospho-Tsc2 [cytosol]
(Rattus norvegicus)
phospho-gig [cytosol]
(Drosophila melanogaster)
phospho-p-S939,T1462-TSC2 [cytosol]
(Bos taurus)
phospho-p-S939,T1462-TSC2 [cytosol]
(Dictyostelium discoideum)
phospho-p-S939,T1462-TSC2 [cytosol]
(Gallus gallus)
phospho-TSC2 [cytosol]
(Canis familiaris)
phospho-TSC2 [cytosol]
(Sus scrofa)
phospho-tsc2 [cytosol]
(Schizosaccharomyces pombe)
phospho-tsc2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 939
Coordinate
939
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 1462
Coordinate
1462
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001305758.1
,
NP_001305761.1
,
NP_001305756.1
,
NP_001107854.1
,
NP_001305760.1
,
XP_005255586.2
,
XP_016879105.1
,
NP_001070651.1
,
NP_000539.2
OpenTargets
ENSG00000103197
GeneCards
P49815
HPA
ENSG00000103197-TSC2
Ensembl
ENSP00000384468
,
ENSP00000494514
,
ENST00000382538
,
ENSP00000219476
,
ENST00000439673
,
ENSP00000399232
,
ENSP00000371978
,
ENST00000401874
,
ENSG00000103197
,
ENSP00000344383
,
ENST00000642936
,
ENST00000219476
,
ENSP00000496262
,
ENST00000350773
,
ENST00000644043
PRO
P49815
Pharos - Targets
P49815
Orphanet
15669
PDB
7DL2
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.945
15
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.937
12
UniProt:Q92574 TSC1
2
TSC1 [plasma membrane]
(R-HSA-165169)
TSC1 [cytosol]
(R-HSA-5672338)
0.935
13
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.87
9
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.851
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.816
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.675
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.571
3
UniProt:O00141 SGK1
4
SGK1 [cytosol]
(R-HSA-2682356)
p-S422-SGK1 [cytosol]
(R-HSA-6795313)
p-T256,S422-SGK1 [cytosol]
(R-HSA-6795449)
p-T256,S422-SGK1 [nucleoplasm]
(R-HSA-9612512)
0.563
4
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.528
3
UniProt:P03126 VE6
0.527
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
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