Reactome | p-S939,T1462-TSC2 [cytosol]

p-S939,T1462-TSC2 [cytosol]

Stable Identifier

R-HSA-199484

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-TSC2

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External Reference Information

External Reference

UniProt:P49815 TSC2

Gene Names

TSC2, TSC4

Chain

chain:1-1807

Reference Genes

BioGPS Gene:7249 TSC2

COSMIC (genes):TSC2 TSC2

CTD Gene:7249 TSC2

dbSNP Gene:7249 TSC2

ENSEMBL:ENSG00000103197 TSC2

HGNC:12363 TSC2

KEGG:hsa:7249 TSC2

Monarch:7249 TSC2

NCBI Gene:7249 TSC2

OMIM:191092 TSC2

UCSC:P49815 TSC2

Reference Transcript

Participates

as an output of

as a component of

p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Homo sapiens)

as an input of

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)

Other forms of this molecule

p-S1387-TSC2 [cytosol]

TSC2 [cytosol]

p-S939,S1130,T1462-TSC2 [cytosol]

Inferred To

phospho-Tsc2 [cytosol] (Mus musculus)

phospho-Tsc2 [cytosol] (Rattus norvegicus)

phospho-gig [cytosol] (Drosophila melanogaster)

phospho-p-S939,T1462-TSC2 [cytosol] (Bos taurus)

phospho-p-S939,T1462-TSC2 [cytosol] (Dictyostelium discoideum)

phospho-p-S939,T1462-TSC2 [cytosol] (Gallus gallus)

phospho-TSC2 [cytosol] (Canis familiaris)

phospho-TSC2 [cytosol] (Sus scrofa)

phospho-tsc2 [cytosol] (Schizosaccharomyces pombe)

phospho-tsc2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 939

Coordinate

939

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 1462

Coordinate

1462

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001357333.1, XP_005255586.2, NP_001305756.1, NP_001107854.1, XP_016879105.1, NP_001305761.1, NP_000539.2, NP_001305758.1, NP_001305760.1, NP_066399.2, NP_001070651.1

ENSEMBL

ENSP00000344383, ENST00000401874, ENSP00000496262, ENSP00000219476, ENSP00000494514, ENST00000644043, ENSP00000399232, ENST00000350773, ENST00000382538, ENSP00000384468, ENST00000219476, ENSG00000103197, ENSP00000371978, ENST00000642936, ENST00000439673

OpenTargets

ENSG00000103197

GeneCards

TSC2

HPA

ENSG00000103197-TSC2

PRO

P49815

Pharos - Targets

P49815

Orphanet

TSC2

GlyGen

P49815

PDB

7DL2, 9CE3

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.949	16
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.937	12
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.935	13
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.87	9
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.86	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.851	8
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.675	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.571	3
UniProt:O00141 SGK1	4	p-T256,S422-SGK1 [nucleoplasm] (R-HSA-9612512) p-T256,S422-SGK1 [cytosol] (R-HSA-6795449) p-S422-SGK1 [cytosol] (R-HSA-6795313) SGK1 [cytosol] (R-HSA-2682356)	0.563	4
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.528	3
UniProt:P03126 VE6			0.527	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2

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