Reactome | Severe acute respiratory syndrome coronavirus 2

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Severe acute respiratory syndrome coronavirus 2 Show undefined attributes

abbreviation	COV
created	[InstanceEdit:9681685] D'Eustachio, Peter, 2020-04-03
crossReference	[DatabaseIdentifier:9681699] NCBI Taxonomy:2697049
dbId	9681683
displayName	Severe acute respiratory syndrome coronavirus 2
modified	[InstanceEdit:9717178] D'Eustachio, Peter, 2021-03-08
name	Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2
schemaClass	Species
superTaxon	[Species:9678119] Human SARS coronavirus
taxId	2697049

Referrals

(relatedSpecies)

[Pathway:R-HSA-9694516] SARS-CoV-2 Infection
[Pathway:R-HSA-9772573] Late SARS-CoV-2 Infection Events
[Pathway:R-HSA-9772572] Early SARS-CoV-2 Infection Events
[Pathway:R-HSA-9694682] SARS-CoV-2 Genome Replication and Transcription
[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome
[Reaction:R-HSA-9694541] SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors
[BlackBoxEvent:R-HSA-9694792] nsp12 misincorporates a nucleotide in nascent RNA minus strand
[Reaction:R-HSA-9694665] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors
[Reaction:R-HSA-9694406] nsp13 binds DDX5
[Reaction:R-HSA-9694520] nsp16 binds VHL
[Reaction:R-HSA-9694677] ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA
[Complex:R-HSA-9698376] ZCRB1:m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[Reaction:R-HSA-9694390] nsp15 binds RB1
[BlackBoxEvent:R-HSA-9755252] nsp15 cleaves viral poly(U)-RNA
[Reaction:R-HSA-9694419] SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors
[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs
[Pathway:R-HSA-9694676] Translation of Replicase and Assembly of the Replication Transcription Complex
[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
[Pathway:R-HSA-9694301] Maturation of replicase proteins
[BlackBoxEvent:R-HSA-9731274] nsp16 localizes to the nucleus
[BlackBoxEvent:R-HSA-9694592] 3CLp dimer binds 3CLp inhibitors
[BlackBoxEvent:R-HSA-9731262] nsp6 localizes to the nuclear envelope
[BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer
[Reaction:R-HSA-9732822] nsp3 binds to PLpro inhibitors
[Reaction:R-HSA-9731708] nsp10:nsp14 binds to ExoN inhibitors
[BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation
[BlackBoxEvent:R-HSA-9694580] nsp8 binds MAP1LC3B
[Pathway:R-HSA-9694614] Attachment and Entry
[Reaction:R-HSA-9707827] Spike binds Spike inhibitors
[Pathway:R-HSA-9694635] Translation of Structural Proteins
[Pathway:R-HSA-9694493] Maturation of protein E
[BlackBoxEvent:R-HSA-9694790] E protein gets N-glycosylated
[Pathway:R-HSA-9694719] Maturation of protein 3a
[BlackBoxEvent:R-HSA-9694727] Endocytosis of protein 3a
[Pathway:R-HSA-9694548] Maturation of spike protein
[Pathway:R-HSA-9694631] Maturation of nucleoprotein
[BlackBoxEvent:R-HSA-9694575] Nucleoprotein translocates to the plasma membrane
[BlackBoxEvent:R-HSA-9694345] Nucleoprotein translocates to the nucleolus
[BlackBoxEvent:R-HSA-9694373] Unphosphorylated nucleoprotein translocates to the plasma membrane
[Pathway:R-HSA-9694594] Maturation of protein M
[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion
[Reaction:R-HSA-9770187] S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2
[Complex:R-HSA-9770062] S1:ACE2 [plasma membrane]
[Reaction:R-HSA-9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
[Complex:R-HSA-9733494] S1 trimer:ACE2:S2 trimer [plasma membrane]
[Reaction:R-HSA-9733495] Viral Spike Binds to ACE2 on Uninfected Cell
[Complex:R-HSA-9770060] Spike trimer:ACE2 [plasma membrane]
[BlackBoxEvent:R-HSA-9769812] Spike Trimer Translocates to the Plasma Membrane
[Pathway:R-HSA-9727281] Translation of Accessory Proteins
[Reaction:R-HSA-9758486] Unknown kinase phosphorylates 9b
[Pathway:R-HSA-9694322] Virion Assembly and Release
[Complex:R-HSA-9694566] nsp8:MAP1LC3B [cytosol]
[Complex:R-HSA-9694692] nsp13:DDX5 [cytosol]
[Complex:R-HSA-9694398] nsp16:VHL [cytosol]
[Complex:R-HSA-9694258] nsp15:RB1 [cytosol]
[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
[Complex:R-HSA-975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
[Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
[Complex:R-HSA-975132] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975130] p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975161] pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]
[Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
[Reaction:R-HSA-975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9
[Reaction:R-HSA-167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands
[Complex:R-HSA-9691207] TLR8 dimer:TLR7,TLR8 ligands [endosome membrane]
[Complex:R-HSA-975124] MyD88 complexed with the activated TLR receptor [endosome membrane]
[Complex:R-HSA-975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975133] p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975146] IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975107] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
[Complex:R-HSA-975114] oligo-MyD88:activated TLR7-9 [endosome membrane]
[DefinedSet:R-HSA-975158] Activated TLR7-9 homodimers [endosome membrane]
[Complex:R-HSA-188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane]
[Pathway:R-HSA-9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction
[Reaction:R-HSA-190541] Association of Cx43 with TJP1
[Reaction:R-HSA-9705681] MPP5 binds SARS-CoV-2 E pentamer
[Complex:R-HSA-9705682] MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9754644] SARS-CoV-2 E pentamer binds TJP1
[Complex:R-HSA-9754656] TJP1:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Pathway:R-HSA-9755779] SARS-CoV-2 targets host intracellular signalling and regulatory pathways
[Reaction:R-HSA-9729500] SARS-CoV-2 N binds to 14-3-3 proteins
[Complex:R-HSA-9729509] 14-3-3 dimer:N [cytosol]
[Reaction:R-HSA-9755777] SARS-CoV-2 M, N bind to PDPK1
[Reaction:R-HSA-9754518] SARS-CoV-2 3a tetramer binds to CAV1
[Complex:R-HSA-9754517] CAV1:3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9756470] N binds to heme
[Pathway:R-HSA-9754560] SARS-CoV-2 modulates autophagy
[BlackBoxEvent:R-HSA-9754554] SARS-COV 7a translocates to the late endosome membrane
[Reaction:R-HSA-9754537] SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex
[Complex:R-HSA-9754533] HOPS:3a [endolysosome membrane]
[Reaction:R-HSA-9730505] SARS-CoV-2 3a binds to UVRAG
[Complex:R-HSA-9730524] UVRAG:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[BlackBoxEvent:R-HSA-9754775] SARS-CoV-2 M protein binds MAP1LC3B
[BlackBoxEvent:R-HSA-9754763] SARS-CoV-2 M protein binds TUFM
[Complex:R-HSA-9755946] MAP1LC3B:TUFM:M [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-HSA-9754785] TUFM:M [endoplasmic reticulum membrane]
[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses
[Reaction:R-HSA-9757097] SARS-CoV-2 N binds NLRP3
[Complex:R-HSA-9757077] N:NLRP3 [cytosol]
[Reaction:R-HSA-9729704] SARS-CoV-2 3CLpro dimer cleaves TAB1
[Reaction:R-HSA-9705320] TBK1, IKBKE are autophosphorylated at Ser172
[Reaction:R-HSA-9755368] TLR2:TLR1 binds SARS-CoV-2 E pentamer
[Complex:R-HSA-9755412] TLR2:TLR1:E:S3:M:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [plasma membrane]
[Reaction:R-HSA-9729454] SARS-CoV-2 N protein binds STAT1, STAT2
[Reaction:R-HSA-9755757] SARS-CoV-2 N binds TAK1
[Reaction:R-HSA-9755747] SARS-CoV-2 N binds MAVS
[Complex:R-HSA-9755729] N:MAVS [cytosol]
[Reaction:R-HSA-9730528] SARS-CoV-2 3a binds to STING
[Complex:R-HSA-9730525] STING:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9705082] SARS-CoV-2 nsp13 binds TBK1
[Complex:R-HSA-9705087] TBK1:pp1ab-nsp13 [cytosol]
[Reaction:R-HSA-9755258] DDX58 binds SARS-CoV-2 dsRNA intermediates
[Complex:R-HSA-9755962] SARS-CoV-2 dsRNA intermediates:DDX58 [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9754745] IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates
[Reaction:R-HSA-9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
[Complex:R-HSA-9754743] SARS-CoV-2 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9754616] SARS-CoV-2 E pentamer transports Ca2+
[Reaction:R-HSA-9760510] LARP1 binds SARS-CoV-2 RNA
[Complex:R-HSA-9760493] LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9705010] SARS-CoV-2 nsp6 binds TBK1
[Complex:R-HSA-9705026] TBK1:pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9755765] C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA
[Complex:R-HSA-9755742] TLR7 dimer:SARS-CoV-2 ssRNA [endosome membrane]
[Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
[BlackBoxEvent:R-HSA-9754827] SARS-CoV-2 M binds TBK1
[Complex:R-HSA-9754834] M:TBK1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-918224] DDX58 is K63 polyubiquitinated
[Reaction:R-HSA-9729481] SARS-CoV-2 N binds to G3BP1,G3BP2
[Complex:R-HSA-9729513] G3BP1,G3BP2:N [cytosol]
[Reaction:R-HSA-9768142] Dimerized phospho-IRF3, IRF7 is transported to the nucleus
[Reaction:R-HSA-9756494] CREBBP acetylates SARS-CoV-2 N at K375
[Reaction:R-HSA-9754830] TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA
[Complex:R-HSA-9754831] TLR8 dimer:SARS-CoV-2 ssRNA [endosome membrane]
[Reaction:R-HSA-9729741] SARS-CoV-2 3CLpro dimer cleaves NLRP12
[Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3
[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
[Reaction:R-HSA-9758529] SARS-CoV-2 N binds MASP2
[Complex:R-HSA-9758533] N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
[BlackBoxEvent:R-HSA-9716160] SARS-CoV-2 M protein binds MAVS
[Complex:R-HSA-9755714] M:MAVS [endoplasmic reticulum membrane]
[Complex:R-HSA-9729443] STAT1,STAT2:N [cytosol]
[Reaction:R-HSA-9730501] SARS-CoV-2 3CLpro dimer binds to STING
[Complex:R-HSA-9730518] STING:3CLpro dimer [cytosol]
[Reaction:R-HSA-9717658] SARS-CoV-2 N binds DDX58
[Complex:R-HSA-9717677] DDX58:N [cytosol]
[Reaction:R-HSA-9708889] SARS-CoV-2 6 binds NUP98:RAE1 within NPC
[BlackBoxEvent:R-HSA-9727293] 6 localizes to the nuclear envelope
[Complex:R-HSA-9708891] 6:NPC [nuclear envelope]
[Reaction:R-HSA-9730521] SARS-CoV-2 3a induces potassium efflux
[BlackBoxEvent:R-HSA-9694572] 3a localizes to the cell membrane
[BlackBoxEvent:R-HSA-9694308] 3a is externalized together with membrane structures
[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1
[Reaction:R-HSA-9755328] SARS-CoV-2 8 binds class I MHC
[Reaction:R-HSA-9755354] 8 forms a homodimer
[BlackBoxEvent:R-HSA-9727305] mRNA8 is translated to protein 8
[Complex:R-HSA-9755322] 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]
[Complex:R-HSA-9755340] 8:antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane]
[Reaction:R-HSA-9709663] SARS-CoV-2 9b binds TOMM70
[Reaction:R-HSA-9756574] SARS-CoV-2 S binds SFTPD 12mer
[Complex:R-HSA-9756571] SFTPD:S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
[Reaction:R-HSA-9729437] SARS-CoV-2 N binds to TRIM25
[Complex:R-HSA-9729447] TRIM25:N [cytosol]
[Reaction:R-HSA-9759709] CNBP binds SARS-CoV-2 G-rich RNA
[Complex:R-HSA-9759705] CNBP:SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9709852] MAVS:TOMM70 recruits HSP90:TBK1:IRF3
[Complex:R-HSA-9709659] TOMM70:9b [mitochondrial outer membrane]
[Reaction:R-HSA-9705299] SARS-CoV-2 6 binds KPNA2
[BlackBoxEvent:R-HSA-9727292] mRNA6 is translated to protein 6
[Complex:R-HSA-9705285] KPNA2:6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9754839] SARS-CoV-2 9b binds IKBKG
[BlackBoxEvent:R-HSA-9727300] 9b homodimer localizes to the mitochondrial outer membrane
[BlackBoxEvent:R-HSA-9727284] 9b forms a homodimer
[BlackBoxEvent:R-HSA-9727303] mRNA9 is translated to protein 9b
[Complex:R-HSA-9754828] 9b:IKK complex [mitochondrial outer membrane]
[Reaction:R-HSA-9755734] SARS-CoV-2 N binds IKBKB
[Reaction:R-HSA-9755413] SARS-CoV-2 8 binds IL17RA
[Complex:R-HSA-9755355] 8:IL17RA [plasma membrane]
[Pathway:R-HSA-9754678] SARS-CoV-2 modulates host translation machinery
[Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA
[Complex:R-HSA-9729785] 7SL RNA:nsp9 tetramer [cytosol]
[Reaction:R-HSA-9729849] SARS-CoV-2 nsp1 binds to 40S ribosomal complex
[Complex:R-HSA-9729832] 40S ribosomal complex:nsp1 [cytosol]
[Reaction:R-HSA-9730488] SARS-CoV-2 nsp16 binds to U2 snRNA
[Complex:R-HSA-9730482] U2 snRNA:nsp16 [nucleoplasm]
[Reaction:R-HSA-9730483] SARS-CoV-2 nsp16 binds to U1 snRNA
[Complex:R-HSA-9730486] U1 snRNA:nsp16 [nucleoplasm]
[Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA
[Reaction:R-HSA-9694441] 3CLp cleaves pp1a
[BlackBoxEvent:R-HSA-9694334] mRNA1 is translated to pp1a
[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome
[Reaction:R-HSA-9694689] Fusion and Release of SARS-CoV-2 Nucleocapsid
[Reaction:R-HSA-9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
[Reaction:R-HSA-9694287] Cleavage of S protein into S1:S2
[Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion
[Reaction:R-HSA-9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
[Reaction:R-HSA-9694641] Viral release
[Reaction:R-HSA-9694633] SARS virus buds into ERGIC lumen
[Reaction:R-HSA-9694528] Accessory proteins are recruited to the maturing virion
[BlackBoxEvent:R-HSA-9727288] 7a localizes to the ERGIC membrane
[BlackBoxEvent:R-HSA-9727297] mRNA7 is translated to protein 7a
[Reaction:R-HSA-9694553] Recruitment of Spike trimer to assembling virion
[Reaction:R-HSA-9694444] E and N are recruited to the M lattice
[Reaction:R-HSA-9694281] Encapsidation of SARS coronavirus genomic RNA
[Reaction:R-HSA-9694455] SUMO-p-N protein dimer binds genomic RNA
[BlackBoxEvent:R-HSA-9694568] Nucleoprotein translocates to the ERGIC outer membrane
[BlackBoxEvent:R-HSA-9694294] E pentamer is transported to the Golgi
[Reaction:R-HSA-9694452] Protein E forms a homopentamer
[BlackBoxEvent:R-HSA-9694529] Ubiquination of protein E
[Reaction:R-HSA-9694401] E protein gets palmitoylated
[BlackBoxEvent:R-HSA-9694280] mRNA4 is translated to protein E
[Reaction:R-HSA-9694487] M protein oligomerization
[BlackBoxEvent:R-HSA-9694367] Glycosylated M localizes to the Golgi membrane
[BlackBoxEvent:R-HSA-9694525] M protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9694555] Protein M localizes to the Golgi membrane
[BlackBoxEvent:R-HSA-9694681] mRNA5 is translated to protein M
[BlackBoxEvent:R-HSA-9697018] Addition of sialic acids on some Spike glycosyl sidechains
[BlackBoxEvent:R-HSA-9696980] Spike trimer glycoside chains get additional branches
[BlackBoxEvent:R-HSA-9694656] Spike trimer glycoside chains are extended
[Reaction:R-HSA-9694467] Spike protein forms a homotrimer
[Reaction:R-HSA-9694341] Spike protein gets palmitoylated
[BlackBoxEvent:R-HSA-9694780] Spike translocates to ERGIC
[Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin
[BlackBoxEvent:R-HSA-9696807] N-glycan mannose trimming of Spike
[BlackBoxEvent:R-HSA-9694364] N-glycan glucose trimming of Spike
[BlackBoxEvent:R-HSA-9694793] Spike protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9694447] mRNA2 is translated to Spike
[Reaction:R-HSA-9694662] Protein 3a forms a homotetramer
[Reaction:R-HSA-9694718] O-glycosylation of 3a is terminated
[Reaction:R-HSA-9694438] GalNAc is transferred onto 3a
[BlackBoxEvent:R-HSA-9694392] 3a translocates to the ERGIC
[BlackBoxEvent:R-HSA-9694794] mRNA3 is translated to protein 3a
[BlackBoxEvent:R-HSA-9694733] Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)
[Reaction:R-HSA-9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
[BlackBoxEvent:R-HSA-9694476] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs
[Reaction:R-HSA-9815529] nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs
[BlackBoxEvent:R-HSA-9694506] Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs
[BlackBoxEvent:R-HSA-9694344] Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching
[BlackBoxEvent:R-HSA-9694265] nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template
[Reaction:R-HSA-9694454] Replication transcription complex binds SARS-CoV-2 genomic RNA
[BlackBoxEvent:R-HSA-9694576] nsp3 binds to nsp7-8 and nsp12-16
[Reaction:R-HSA-9694445] nsp16 binds nsp10
[Reaction:R-HSA-9694539] nsp15 binds nsp8
[Reaction:R-HSA-9694524] nsp13 binds nsp12
[Reaction:R-HSA-9694304] nsp14 binds nsp12
[Reaction:R-HSA-9694542] nsp14 binds nsp10
[Reaction:R-HSA-9691363] nsp12 binds nsp7 and nsp8
[Reaction:R-HSA-9691335] nsp7 binds nsp8
[Reaction:R-HSA-9765952] nsp12 guanylates nsp7
[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors
[Reaction:R-HSA-9694436] nsp15 forms a hexamer
[BlackBoxEvent:R-HSA-9694630] Nsp3:nsp4 binds to nsp6
[BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles
[Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11
[BlackBoxEvent:R-HSA-9694611] nsp4 is glycosylated
[Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4
[BlackBoxEvent:R-HSA-9694389] nsp3 is glycosylated
[Reaction:R-HSA-9694601] nsp3-4 cleaves itself
[BlackBoxEvent:R-HSA-9694331] nsp3-4 is glycosylated
[Reaction:R-HSA-9694338] nsp1-4 cleaves itself
[Reaction:R-HSA-9694732] 3CLp cleaves pp1ab
[Reaction:R-HSA-9694333] 3CLp forms a homodimer
[BlackBoxEvent:R-HSA-9694274] mRNA1 is translated to pp1ab
[BlackBoxEvent:R-HSA-9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand)
[Reaction:R-HSA-9694721] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
[BlackBoxEvent:R-HSA-9694737] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
[BlackBoxEvent:R-HSA-9694581] RTC synthesizes SARS-CoV-2 plus strand genomic RNA
[Reaction:R-HSA-9694495] RTC binds SARS-CoV-2 genomic RNA complement (minus strand)
[Reaction:R-HSA-9694521] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
[BlackBoxEvent:R-HSA-9694492] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
[BlackBoxEvent:R-HSA-9694549] RTC completes synthesis of the minus strand genomic RNA complement
[BlackBoxEvent:R-HSA-9694605] nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement
[BlackBoxEvent:R-HSA-9694277] nsp8 generates RNA primers
[Complex:R-HSA-9694758] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen]
[Reaction:R-HSA-9694632] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
[Reaction:R-HSA-9694377] pp1a cleaves itself
[BlackBoxEvent:R-HSA-9694567] pp1a forms a dimer
[Reaction:R-HSA-9694363] Dimerisation of nucleoprotein
[Reaction:R-HSA-9729307] Nucleoprotein is SUMOylated
[Reaction:R-HSA-9729279] Nucleoprotein is ADP-ribosylated
[Reaction:R-HSA-9729283] Nucleoprotein is methylated by PRMT1
[Reaction:R-HSA-9729300] Unknown kinase phosphorylates nucleoprotein
[Reaction:R-HSA-9729318] CSNK1A1 phosphorylates nucleoprotein
[Reaction:R-HSA-9729260] GSK3 phosphorylates nucleoprotein
[Reaction:R-HSA-9729330] SRPK1/2 phosphorylates nucleoprotein
[BlackBoxEvent:R-HSA-9694370] mRNA9a is translated to Nucleoprotein
[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
[BlackBoxEvent:R-HSA-9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
[Complex:R-HSA-9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]
[Complex:R-HSA-9755778] N:M:PDPK1 [plasma membrane]
[Complex:R-HSA-9957204] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region]
[DefinedSet:R-HSA-3266545] MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane]
[DefinedSet:R-HSA-166763] C4 activators [plasma membrane]
[Complex:R-HSA-9957085] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Ca2+ [extracellular region]
[DefinedSet:R-HSA-3266540] MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane]
[Reaction:R-HSA-9957161] MBL2 binds SARS-CoV-2 S
[Reaction:R-HSA-166726] Activation of MASPs
[Complex:R-HSA-9755745] N:TAK1complex [cytosol]
[Complex:R-HSA-9755930] N:CHUK:IKBKB:IKBKG [cytosol]
[Complex:R-HSA-9729808] 7SL RNA:nsp8 [cytosol]

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