Reactome | SARS-CoV-2 activates/modulates innate and adaptive immune responses

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SARS-CoV-2 activates/modulates innate and adaptive immune responses Show undefined attributes

authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27 [InstanceEdit:9729688] Stephan, Ralf, 2021-05-03
created	[InstanceEdit:9705656] Shamovsky, Veronica, 2020-10-28
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9705671
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 activates/modulates innate and adaptive immune responses
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9755765] C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA - Homo sapiens [Reaction:R-HSA-9754830] TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA - Homo sapiens [Reaction:R-HSA-9754745] IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates - Homo sapiens [Reaction:R-HSA-9755258] DDX58 binds SARS-CoV-2 dsRNA intermediates - Homo sapiens [Reaction:R-HSA-9755368] TLR2:TLR1 binds SARS-CoV-2 E pentamer - Homo sapiens [Reaction:R-HSA-9759709] CNBP binds SARS-CoV-2 G-rich RNA - Homo sapiens [Reaction:R-HSA-9760510] LARP1 binds SARS-CoV-2 RNA - Homo sapiens [Reaction:R-HSA-9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 - Homo sapiens [Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 - Homo sapiens [Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3 - Homo sapiens [Reaction:R-HSA-9705010] SARS-CoV-2 nsp6 binds TBK1 - Homo sapiens [Reaction:R-HSA-9705082] SARS-CoV-2 nsp13 binds TBK1 - Homo sapiens [BlackBoxEvent:R-HSA-9716160] SARS-CoV-2 M protein binds MAVS - Homo sapiens [BlackBoxEvent:R-HSA-9754827] SARS-CoV-2 M binds TBK1 - Homo sapiens [Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 - Homo sapiens [Reaction:R-HSA-9705320] TBK1, IKBKE are autophosphorylated at Ser172 - Homo sapiens [Reaction:R-HSA-9755747] SARS-CoV-2 N binds MAVS - Homo sapiens [Reaction:R-HSA-9756494] CREBBP acetylates SARS-CoV-2 N at K375 - Homo sapiens [Reaction:R-HSA-9717658] SARS-CoV-2 N binds DDX58 - Homo sapiens [Reaction:R-HSA-9729437] SARS-CoV-2 N binds to TRIM25 - Homo sapiens [Reaction:R-HSA-918224] DDX58 is K63 polyubiquitinated - Homo sapiens [Reaction:R-HSA-9729481] SARS-CoV-2 N binds to G3BP1,G3BP2 - Homo sapiens [Reaction:R-HSA-9755757] SARS-CoV-2 N binds TAK1 - Homo sapiens [Reaction:R-HSA-9755734] SARS-CoV-2 N binds IKBKB - Homo sapiens [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens [Reaction:R-HSA-9729454] SARS-CoV-2 N protein binds STAT1, STAT2 - Homo sapiens [Reaction:R-HSA-909726] Phosphorylation of STAT1 - Homo sapiens [Reaction:R-HSA-9757097] SARS-CoV-2 N binds NLRP3 - Homo sapiens [Reaction:R-HSA-9758529] SARS-CoV-2 N binds MASP2 - Homo sapiens [Reaction:R-HSA-9754616] SARS-CoV-2 E pentamer transports Ca2+ - Homo sapiens [Reaction:R-HSA-9729741] SARS-CoV-2 3CLpro dimer cleaves NLRP12 - Homo sapiens [Reaction:R-HSA-9729704] SARS-CoV-2 3CLpro dimer cleaves TAB1 - Homo sapiens [Reaction:R-HSA-9730501] SARS-CoV-2 3CLpro dimer binds to STING - Homo sapiens [Reaction:R-HSA-9730528] SARS-CoV-2 3a binds to STING - Homo sapiens [Reaction:R-HSA-9730521] SARS-CoV-2 3a induces potassium efflux - Homo sapiens [Reaction:R-HSA-9705299] SARS-CoV-2 6 binds KPNA2 - Homo sapiens [Reaction:R-HSA-9708889] SARS-CoV-2 6 binds NUP98:RAE1 within NPC - Homo sapiens [Reaction:R-HSA-9768142] Dimerized phospho-IRF3, IRF7 is transported to the nucleus - Homo sapiens [Reaction:R-HSA-9709663] SARS-CoV-2 9b binds TOMM70 - Homo sapiens [Reaction:R-HSA-9709852] MAVS:TOMM70 recruits HSP90:TBK1:IRF3 - Homo sapiens [Reaction:R-HSA-9754839] SARS-CoV-2 9b binds IKBKG - Homo sapiens [Reaction:R-HSA-9755328] SARS-CoV-2 8 binds class I MHC - Homo sapiens [Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1 - Homo sapiens [Reaction:R-HSA-983426] Capturing cargo and formation of prebudding complex - Homo sapiens [Reaction:R-HSA-9755413] SARS-CoV-2 8 binds IL17RA - Homo sapiens [BlackBoxEvent:R-HSA-447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - Homo sapiens [Reaction:R-HSA-9756574] SARS-CoV-2 S binds SFTPD 12mer - Homo sapiens [Reaction:R-HSA-9957161] MBL2 binds SARS-CoV-2 S - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:9705074] Evasion of Type I Interferon by SARS-CoV-2 [LiteratureReference:9705680] Interplay between SARS-CoV-2 and the type I interferon response [LiteratureReference:9705662] Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19 [LiteratureReference:9755756] Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators [LiteratureReference:9756650] Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV [LiteratureReference:9756653] Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 [LiteratureReference:9756655] Type I Interferons in COVID-19 Pathogenesis
maxDepth	2
modified	[InstanceEdit:9971503] Shamovsky, Veronica, 2025-11-07
name	SARS-CoV-2 activates/modulates innate and adaptive immune responses
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9705671
summation	[Summation:9705679] Coronaviruses (CoVs) are positive-sense RNA viruses that rep...
updateTrackers	[UpdateTracker:9971951] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v95:[removeHasEvent] [UpdateTracker:9774781] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v81:[updateContainedRLE] [UpdateTracker:9846787] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v84:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions

(updatedInstance)

[UpdateTracker:9971951] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v95:[removeHasEvent]
[UpdateTracker:9774781] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v81:[updateContainedRLE]
[UpdateTracker:9846787] Update Tracker - [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - v84:[updateContainedRLE]

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