Reactome | Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex

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Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
category	dissociation
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975100
displayName	Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens
input	[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
orthologousEvent	[Reaction:R-GGA-532630] p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 - Gallus gallus
output	4 × [Complex:R-HSA-975126] hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] [Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
precedingEvent	[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975100
summation	[Summation:940394] Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociat...
updateTrackers	[UpdateTracker:9788152] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v43:[modifyText] [UpdateTracker:9788511] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788152] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v43:[modifyText] [UpdateTracker:9788511] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v41:[modifyText]
(hasEvent)	[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
(precedingEvent)	[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

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