Reactome | E protein gets palmitoylated

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E protein gets palmitoylated Show undefined attributes

authored	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694401
disease	[Disease:9683912] COVID-19
displayName	E protein gets palmitoylated
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694493] Maturation of protein E - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9694529] Ubiquination of protein E - Homo sapiens
inferredFrom	[Reaction:R-HSA-9683720] E protein gets palmitoylated - Homo sapiens
input	[EntityWithAccessionedSequence:R-COV-9694312] nascent E [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-9683736] palmitoyl-CoA [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9682946] Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein [LiteratureReference:9682971] Palmitoylation of virus proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E protein gets palmitoylated
output	[EntityWithAccessionedSequence:R-COV-9694305] 3xPalmC-E [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-162743] CoA-SH [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-9694280] mRNA4 is translated to protein E - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694401
summation	[Summation:9694540] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. Viral E protein is modified by palmitoylation at all three cysteine residues. In general, palmitoylation is usually non-enzymatic (Liao et al, 2006, Veit, 2012).

Referrals

(hasEvent)	[Pathway:R-HSA-9694493] Maturation of protein E
(precedingEvent)	[BlackBoxEvent:R-HSA-9694529] Ubiquination of protein E
(inferredTo)	[Reaction:R-HSA-9683720] E protein gets palmitoylated