Reactome | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

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TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	975110
displayName	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens [BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex - Homo sapiens [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation - Homo sapiens [Reaction:R-HSA-933533] Dimerization of p-IRF7 - Homo sapiens [Reaction:R-HSA-933531] Translocation of p-IRF7:p-IRF7 to nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:168931] Regulation of the type I IFN induction: a current view [LiteratureReference:500625] Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
orthologousEvent	[Pathway:R-GGA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Gallus gallus [Pathway:R-XTR-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Xenopus tropicalis [Pathway:R-DRE-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Danio rerio [Pathway:R-SSC-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Sus scrofa [Pathway:R-BTA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Bos taurus [Pathway:R-RNO-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Rattus norvegicus [Pathway:R-MMU-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Mus musculus
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-975110
summation	[Summation:975136] In plasmacytoid dendritic cell induction of type I IFNs crit...
updateTrackers	[UpdateTracker:9787586] Update Tracker - [Pathway:975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - v44:[updateContainedRLE] [UpdateTracker:9779635] Update Tracker - [Pathway:975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - v65:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787586] Update Tracker - [Pathway:975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - v44:[updateContainedRLE] [UpdateTracker:9779635] Update Tracker - [Pathway:975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - v65:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome