Reactome | FURIN Mediated SARS-CoV-2 Spike Protein Cleavage

Schema > Reaction > Entries

FURIN Mediated SARS-CoV-2 Spike Protein Cleavage Show undefined attributes

authored	[InstanceEdit:9769947] Stephan, Ralf, 2022-03-23
catalystActivity	[CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9769951] Stephan, Ralf, 2022-03-23
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9769949
disease	[Disease:9683912] COVID-19
displayName	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
edited	[InstanceEdit:9796426] Stephan, Ralf, 2022-08-09
eventOf	[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2 - Homo sapiens
input	[Complex:R-HSA-9770060] Spike trimer:ACE2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699000] The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin [LiteratureReference:9765579] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis [LiteratureReference:9765590] Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation [LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells [LiteratureReference:9767485] The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms [LiteratureReference:9733457] Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion [LiteratureReference:9770330] Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site [LiteratureReference:9770280] Proteolytic activation of SARS-CoV-2 spike protein [LiteratureReference:9770340] Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
output	[Complex:R-HSA-9733494] S1 trimer:ACE2:S2 trimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9736953] FURIN translocates to the plasma membrane - Homo sapiens [Reaction:R-HSA-9733495] Viral Spike Binds to ACE2 on Uninfected Cell - Homo sapiens
regulatedBy	[NegativeRegulation:9769499] Negative regulation by 'Spike:heparin [extracellular region]'
regulationReference	[RegulationReference:9769496] Negative regulation by 'Spike:heparin [extracellular region]' The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773891] Gillespie, Marc E, 2022-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9769949
summation	[Summation:9770216] In a SARS-CoV-2 infection the cellular protease furin cleave...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2
(hasEvent)	[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion