Reactome | 3CLp cleaves pp1ab

Schema > Reaction > Entries

3CLp cleaves pp1ab Show undefined attributes

authored	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
catalystActivity	[CatalystActivity:9694394] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694732
disease	[Disease:9683912] COVID-19
displayName	3CLp cleaves pp1ab
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9694406] nsp13 binds DDX5 - Homo sapiens [Reaction:R-HSA-9694520] nsp16 binds VHL - Homo sapiens [BlackBoxEvent:R-HSA-9731274] nsp16 localizes to the nucleus - Homo sapiens [Reaction:R-HSA-9694436] nsp15 forms a hexamer - Homo sapiens [BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors - Homo sapiens [Reaction:R-HSA-9730483] SARS-CoV-2 nsp16 binds to U1 snRNA - Homo sapiens [Reaction:R-HSA-9730488] SARS-CoV-2 nsp16 binds to U2 snRNA - Homo sapiens [Reaction:R-HSA-9705082] SARS-CoV-2 nsp13 binds TBK1 - Homo sapiens [Reaction:R-HSA-9694333] 3CLp forms a homodimer - Homo sapiens [Reaction:R-HSA-9694338] nsp1-4 cleaves itself - Homo sapiens [Reaction:R-HSA-9691335] nsp7 binds nsp8 - Homo sapiens [Reaction:R-HSA-9694542] nsp14 binds nsp10 - Homo sapiens [Reaction:R-HSA-9694524] nsp13 binds nsp12 - Homo sapiens [Reaction:R-HSA-9694445] nsp16 binds nsp10 - Homo sapiens [Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA - Homo sapiens [Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA - Homo sapiens [BlackBoxEvent:R-HSA-9694580] nsp8 binds MAP1LC3B - Homo sapiens [BlackBoxEvent:R-HSA-9731262] nsp6 localizes to the nuclear envelope - Homo sapiens [Reaction:R-HSA-9765952] nsp12 guanylates nsp7 - Homo sapiens [BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer - Homo sapiens [Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4 - Homo sapiens [BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles - Homo sapiens
input	11 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-COV-9682068] pp1ab [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9761243] Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication [LiteratureReference:9761289] Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp cleaves pp1ab
output	[EntityWithAccessionedSequence:R-COV-9694695] pp1ab-nsp1-4 [cytosol] [EntityWithAccessionedSequence:R-COV-9694372] pp1ab-nsp10 [cytosol] [EntityWithAccessionedSequence:R-COV-9682057] pp1ab-nsp12 [cytosol] [EntityWithAccessionedSequence:R-COV-9694642] pp1ab-nsp13 [cytosol] [EntityWithAccessionedSequence:R-COV-9694537] pp1ab-nsp14 [cytosol] [EntityWithAccessionedSequence:R-COV-9694335] pp1ab-nsp15 [cytosol] [EntityWithAccessionedSequence:R-COV-9694647] pp1ab-nsp16 [cytosol] [EntityWithAccessionedSequence:R-COV-9694504] pp1ab-nsp5 [cytosol] [EntityWithAccessionedSequence:R-COV-9694425] pp1ab-nsp6 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-COV-9682061] pp1ab-nsp7 [cytosol] [EntityWithAccessionedSequence:R-COV-9682052] pp1ab-nsp8 [cytosol] [EntityWithAccessionedSequence:R-COV-9694697] pp1ab-nsp9 [cytosol]
precedingEvent	[Reaction:R-HSA-9694333] 3CLp forms a homodimer - Homo sapiens [BlackBoxEvent:R-HSA-9694274] mRNA1 is translated to pp1ab - Homo sapiens
regulatedBy	[NegativeRegulation:9694290] Negative regulation by '3CLp dimer:3CLp inhibitors [cytosol]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694732
summation	[Summation:9694751] Main protease of SARS-CoV-2 (3CLpro, nsp5) cleaves all cleav...
updateTrackers	[UpdateTracker:9774906] Update Tracker - [Reaction:9694732] 3CLp cleaves pp1ab - v80:[add_removeLiteratureReference, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-9694406] nsp13 binds DDX5 [Reaction:R-HSA-9694520] nsp16 binds VHL [BlackBoxEvent:R-HSA-9731274] nsp16 localizes to the nucleus [Reaction:R-HSA-9694333] 3CLp forms a homodimer [Reaction:R-HSA-9694338] nsp1-4 cleaves itself [Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4 [BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles [Reaction:R-HSA-9694436] nsp15 forms a hexamer [BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors [Reaction:R-HSA-9765952] nsp12 guanylates nsp7 [Reaction:R-HSA-9691335] nsp7 binds nsp8 [Reaction:R-HSA-9694542] nsp14 binds nsp10 [Reaction:R-HSA-9694524] nsp13 binds nsp12 [Reaction:R-HSA-9694445] nsp16 binds nsp10 [Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA [Reaction:R-HSA-9730483] SARS-CoV-2 nsp16 binds to U1 snRNA [Reaction:R-HSA-9730488] SARS-CoV-2 nsp16 binds to U2 snRNA [Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA [Reaction:R-HSA-9705082] SARS-CoV-2 nsp13 binds TBK1 [BlackBoxEvent:R-HSA-9694580] nsp8 binds MAP1LC3B [BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer [BlackBoxEvent:R-HSA-9731262] nsp6 localizes to the nuclear envelope
(hasEvent)	[Pathway:R-HSA-9694301] Maturation of replicase proteins
(updatedInstance)	[UpdateTracker:9774906] Update Tracker - [Reaction:9694732] 3CLp cleaves pp1ab - v80:[add_removeLiteratureReference, modifyText]

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