Reactome | SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1

Schema > Reaction > Entries

SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 Show undefined attributes

authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
catalystActivity	[CatalystActivity:9729742] ISG15-specific peptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755238] Shamovsky, Veronica, 2021-10-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9755244
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
followingEvent	[Reaction:R-HSA-9754745] IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-9755926] ISGylated IFIH1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9755246] ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
output	[Complex:R-HSA-918203] IFIH1:TKFC [cytosol] [EntityWithAccessionedSequence:R-HSA-936552] ISG15 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9694389] nsp3 is glycosylated - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9755244
summation	[Summation:9755235] Interferon-induced helicase C domain-containing protein 1 (I...

Referrals

(hasEvent)	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses
(precedingEvent)	[Reaction:R-HSA-9754745] IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates

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