Reactome | IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9

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IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975115
displayName	IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
followingEvent	[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 - Homo sapiens [Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 - Homo sapiens
input	4 × [DefinedSet:R-HSA-937023] IRAK1, IRAK2 [cytosol] [Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory [LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity [LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
maxDepth	1
modified	[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
orthologousEvent	[Reaction:R-GGA-571324] IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex - Gallus gallus
output	[Complex:R-HSA-975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975115
summation	[Summation:450116] MYD88 recruits unphosphorylated, inactive IRAK1 to the IL1 r... [Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
updateTrackers	[UpdateTracker:9788486] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v42:[addLiteratureReference] [UpdateTracker:9782447] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v59:[modifyText] [UpdateTracker:9789594] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788486] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v42:[addLiteratureReference] [UpdateTracker:9782447] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v59:[modifyText] [UpdateTracker:9789594] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v37:[modifyText]
(hasEvent)	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
(precedingEvent)	[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 [Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9

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