Reactome | Fusion and Release of SARS-CoV-2 Nucleocapsid

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Fusion and Release of SARS-CoV-2 Nucleocapsid Show undefined attributes

authored	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
category	dissociation
compartment	[Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694689
disease	[Disease:9683912] COVID-19
displayName	Fusion and Release of SARS-CoV-2 Nucleocapsid
edited	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
eventOf	[Pathway:R-HSA-9694614] Attachment and Entry - Homo sapiens
followingEvent	[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome - Homo sapiens
inferredFrom	[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid - Homo sapiens
input	[Complex:R-COV-9694585] S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9687536] Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fusion and Release of SARS-CoV-2 Nucleocapsid
output	[Complex:R-COV-9694461] encapsidated SARS-CoV-2 genomic RNA (plus strand) [cytosol] [Complex:R-COV-9694534] S1:S2:M:E: 7a:O-glycosyl 3a tetramer [endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-9694287] Cleavage of S protein into S1:S2 - Homo sapiens [Reaction:R-HSA-9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - Homo sapiens [Reaction:R-HSA-9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - Homo sapiens
regulatedBy	[PositiveRegulation:9687542] Positive regulation by 'VCP [cytosol]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694689
summation	[Summation:9694578] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. The SARS-CoV-2 nucleocapsid is released from the host cell endosome into the cytosol. Molecular details of this step are not well worked out. Studies of the infection of the human cultured cells with HCoV-229E coronavirus established a requirement for VCP (transitional endoplasmic reticulum ATPase) protein function for release to occur (Wong et al. 2015). A similar requirement for VCP involvement in SARS-CoV-2 nucleocapsid release is inferred here.

Referrals

(hasEvent)	[Pathway:R-HSA-9694614] Attachment and Entry
(precedingEvent)	[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome
(inferredTo)	[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid