Reactome | Maturation of spike protein

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Maturation of spike protein Show undefined attributes

authored	[InstanceEdit:9696918] Stephan, Ralf, 2020-07-22
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694548
disease	[Disease:9683912] COVID-19
displayName	Maturation of spike protein
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694635] Translation of Structural Proteins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6677] viral protein processing
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9694793] Spike protein gets N-glycosylated - Homo sapiens [BlackBoxEvent:R-HSA-9694364] N-glycan glucose trimming of Spike - Homo sapiens [Reaction:R-HSA-9686790] ER-alpha glucosidases bind ER-alpha glucosidase inhibitors - Homo sapiens [BlackBoxEvent:R-HSA-9696807] N-glycan mannose trimming of Spike - Homo sapiens [Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin - Homo sapiens [BlackBoxEvent:R-HSA-9694780] Spike translocates to ERGIC - Homo sapiens [Reaction:R-HSA-9694341] Spike protein gets palmitoylated - Homo sapiens [Reaction:R-HSA-9694467] Spike protein forms a homotrimer - Homo sapiens [BlackBoxEvent:R-HSA-9694656] Spike trimer glycoside chains are extended - Homo sapiens [BlackBoxEvent:R-HSA-9696980] Spike trimer glycoside chains get additional branches - Homo sapiens [BlackBoxEvent:R-HSA-9697018] Addition of sialic acids on some Spike glycosyl sidechains - Homo sapiens [BlackBoxEvent:R-HSA-9698333] Spike trimer moves into the ERGIC membrane - Homo sapiens
inferredFrom	[Pathway:R-HSA-9683686] Maturation of spike protein - Homo sapiens
isInDisease	true
isInferred	true
lastUpdatedDate	2022-09-14
literatureReference	[LiteratureReference:9683050] Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E [LiteratureReference:9763716] The Importance of Glycosylation in COVID-19 Infection [LiteratureReference:9763712] The glycosylation in SARS-CoV-2 and its receptor ACE2 [LiteratureReference:9763718] Glycosylation of SARS-CoV-2: structural and functional insights [URL:9763719] https://doi.org/10.1101/2021.05.14.444190 [URL:9763717] https://doi.org/10.31083/j.fbl2701003
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Maturation of spike protein
precedingEvent	[BlackBoxEvent:R-HSA-9694447] mRNA2 is translated to Spike - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9694548
summation	[Summation:9694730] This COVID-19 pathway has been created by a combination of c...
updateTrackers	[UpdateTracker:9774743] Update Tracker - [Pathway:9694548] Maturation of spike protein - v81:[addHasEvent, updateContainedRLE] [UpdateTracker:9775518] Update Tracker - [Pathway:9694548] Maturation of spike protein - v78:[updateContainedRLE] [UpdateTracker:9774991] Update Tracker - [Pathway:9694548] Maturation of spike protein - v80:[add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9776417] Update Tracker - [Pathway:9694548] Maturation of spike protein - v76:[updateContainedRLE] [UpdateTracker:9846999] Update Tracker - [Pathway:9694548] Maturation of spike protein - v82:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9774743] Update Tracker - [Pathway:9694548] Maturation of spike protein - v81:[addHasEvent, updateContainedRLE] [UpdateTracker:9775518] Update Tracker - [Pathway:9694548] Maturation of spike protein - v78:[updateContainedRLE] [UpdateTracker:9774991] Update Tracker - [Pathway:9694548] Maturation of spike protein - v80:[add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9776417] Update Tracker - [Pathway:9694548] Maturation of spike protein - v76:[updateContainedRLE] [UpdateTracker:9846999] Update Tracker - [Pathway:9694548] Maturation of spike protein - v82:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9694635] Translation of Structural Proteins
(inferredTo)	[Pathway:R-HSA-9683686] Maturation of spike protein

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