Reactome | Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation

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Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975106
displayName	Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-933533] Dimerization of p-IRF7 - Homo sapiens
input	8 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933500] Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain [LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
output	8 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 4 × [EntityWithAccessionedSequence:R-HSA-450318] p-S477,S479-IRF7 [cytosol] [Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975106
summation	[Summation:975162] IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R...

Referrals

(hasEvent)	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
(precedingEvent)	[Reaction:R-HSA-933533] Dimerization of p-IRF7

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