Reactome | N-glycan mannose trimming of Spike

Schema > BlackBoxEvent > Entries

N-glycan mannose trimming of Spike Show undefined attributes

authored	[InstanceEdit:9696918] Stephan, Ralf, 2020-07-22
catalystActivity	[CatalystActivity:901026] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
category	uncertain
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9696929] Stephan, Ralf, 2020-07-30
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9696807
disease	[Disease:9683912] COVID-19
displayName	N-glycan mannose trimming of Spike
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694548] Maturation of spike protein - Homo sapiens
followingEvent	[Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin - Homo sapiens
input	[EntityWithAccessionedSequence:R-COV-9696892] Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9696910] Site-specific glycan analysis of the SARS-CoV-2 spike
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	N-glycan mannose trimming of Spike
output	[EntityWithAccessionedSequence:R-COV-9696875] high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-9694364] N-glycan glucose trimming of Spike - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9696807
summation	[Summation:9696836] Except for position 234, all Man(9)-N-glycan modifications o...

Referrals

(hasEvent)	[Pathway:R-HSA-9694548] Maturation of spike protein
(precedingEvent)	[Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin

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