Reactome | Toll Like Receptor 7/8 (TLR7/8) Cascade

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Toll Like Receptor 7/8 (TLR7/8) Cascade Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	168181
displayName	Toll Like Receptor 7/8 (TLR7/8) Cascade
edited	[InstanceEdit:1014284] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258822] toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - Homo sapiens [Reaction:R-HSA-9679029] C-ter TLR7 dimer binds HCQ - Homo sapiens [Reaction:R-HSA-9724670] C-ter TLR7 dimer binds imiquimod - Homo sapiens [Reaction:R-HSA-9691204] TLR8 dimer binds TLR7, TLR8 ligands - Homo sapiens [Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens [Pathway:R-HSA-9860276] SLC15A4:TASL-dependent IRF5 activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:188144] Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
maxDepth	8
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Toll Like Receptor 7/8 (TLR7/8) Cascade
orthologousEvent	[Pathway:R-RNO-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Rattus norvegicus [Pathway:R-CFA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Canis familiaris [Pathway:R-BTA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Bos taurus [Pathway:R-SSC-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Sus scrofa [Pathway:R-DRE-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Danio rerio [Pathway:R-XTR-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Xenopus tropicalis [Pathway:R-GGA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Gallus gallus [Pathway:R-DME-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Drosophila melanogaster [Pathway:R-CEL-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Caenorhabditis elegans [Pathway:R-DDI-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Dictyostelium discoideum [Pathway:R-SPO-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Schizosaccharomyces pombe [Pathway:R-SCE-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Saccharomyces cerevisiae [Pathway:R-PFA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Plasmodium falciparum [Pathway:R-MMU-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188962] Gale M, Jr, 2006-10-31 16:45:01 [InstanceEdit:983288] Gillespie, ME, 2010-10-29 [InstanceEdit:9909272] L�w, Christian, 2024-05-02 [InstanceEdit:9909426] Heinz, Leonhard X, 2024-05-13 [InstanceEdit:9910549] Toyama-Sorimachi, Noriko, 2024-11-15
revised	[InstanceEdit:525804] Shamovsky, V, 2010-02-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168181
summation	[Summation:188294] RNA can serve as a danger signal, both in its double-strande...
updateTrackers	[UpdateTracker:9776868] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9863983] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v88:[updateContainedRLE] [UpdateTracker:9790320] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v34:[removeHasEvent] [UpdateTracker:9788690] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v41:[updateIndirectRLE] [UpdateTracker:9790065] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v35:[addHasEvent] [UpdateTracker:9788415] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776930] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v73:[modifyText, updateContainedRLE] [UpdateTracker:9789948] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v36:[updateContainedRLE] [UpdateTracker:9775473] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v79:[updateContainedRLE] [UpdateTracker:9789614] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v37:[updateIndirectRLE] [UpdateTracker:9791791] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v25:[updateIndirectRLE] [UpdateTracker:9790740] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v33:[updateContainedPathway] [UpdateTracker:9776325] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v76:[modifyText, updateContainedRLE] [UpdateTracker:9789344] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v38:[addLiteratureReference, modifyText] [UpdateTracker:9788910] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v39:[updateContainedRLE] [UpdateTracker:9911026] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v89:[addHasEvent, modifyText] [UpdateTracker:9788311] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v43:[updateIndirectRLE] [UpdateTracker:9782074] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v59:[updateIndirectRLE] [UpdateTracker:9774794] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v81:[addHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-168898] Toll-like Receptor Cascades

(updatedInstance)

[UpdateTracker:9776868] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9863983] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v88:[updateContainedRLE]
[UpdateTracker:9790320] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v34:[removeHasEvent]
[UpdateTracker:9788690] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v41:[updateIndirectRLE]
[UpdateTracker:9790065] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v35:[addHasEvent]
[UpdateTracker:9788415] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9776930] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v73:[modifyText, updateContainedRLE]
[UpdateTracker:9789948] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v36:[updateContainedRLE]
[UpdateTracker:9775473] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v79:[updateContainedRLE]
[UpdateTracker:9789614] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v37:[updateIndirectRLE]
[UpdateTracker:9791791] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v25:[updateIndirectRLE]
[UpdateTracker:9790740] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v33:[updateContainedPathway]
[UpdateTracker:9776325] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v76:[modifyText, updateContainedRLE]
[UpdateTracker:9789344] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9788910] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v39:[updateContainedRLE]
[UpdateTracker:9911026] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v89:[addHasEvent, modifyText]
[UpdateTracker:9788311] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v43:[updateIndirectRLE]
[UpdateTracker:9782074] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v59:[updateIndirectRLE]
[UpdateTracker:9774794] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v81:[addHasEvent]

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