Reactome | TBK1, IKBKE are autophosphorylated at Ser172

Schema > Reaction > Entries

TBK1, IKBKE are autophosphorylated at Ser172 Show undefined attributes

authored	[InstanceEdit:9710238] Shamovsky, Veronica, 2020-12-25
catalystActivity	[CatalystActivity:9705335] protein serine/threonine kinase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9705331] protein serine/threonine kinase activity of dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKKi [mitochondrial outer membrane] Crystal structure and mechanism of activation of TANK-binding kinase 1
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9705319] Shamovsky, Veronica, 2020-10-22
dbId	9705320
displayName	TBK1, IKBKE are autophosphorylated at Ser172
edited	[InstanceEdit:9716568] Shamovsky, Veronica, 2021-02-22
eventOf	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens [Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9705133] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:2408458] Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation [LiteratureReference:9705315] IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
maxDepth	1
modified	[InstanceEdit:9835850] Shamovsky, Veronica, 2023-05-18
name	TBK1, IKBKE are autophosphorylated at Ser172
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-9705137] TBK1 or IKBKE forms homodimers - Homo sapiens
regulatedBy	[NegativeRegulation:9705329] Negative regulation by 'TBK1:pp1ab-nsp13 [cytosol]'
regulationReference	[RegulationReference:9705326] Negative regulation by 'TBK1:pp1ab-nsp13 [cytosol]' Evasion of Type I Interferon by SARS-CoV-2
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2 [Species:9717528] Human respiratory syncytial virus A
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713624] D'Eustachio, Peter, 2021-01-27 [InstanceEdit:9727967] Ramos, Carlos H I, 2021-04-19 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705320
summation	[Summation:9705332] Viral nucleic acids are sensed by cellular pattern-recogniti...
updateTrackers	[UpdateTracker:9774950] Update Tracker - [Reaction:9705320] TBK1, IKBKE are autophosphorylated at Ser172 - v80:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9774950] Update Tracker - [Reaction:9705320] TBK1, IKBKE are autophosphorylated at Ser172 - v80:[addRegulator]
(hasEvent)	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway [Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses