Reactome | Activation of MASPs

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Activation of MASPs Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:166725] de Bono, B, 2005-09-15 14:33:08
dbId	166726
displayName	Activation of MASPs
eventOf	[Pathway:R-HSA-166662] Lectin pathway of complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-166753] Conversion of C4 into C4a and C4b - Homo sapiens [Reaction:R-HSA-166792] Conversion of C2 into C2a and C2b - Homo sapiens
input	[DefinedSet:R-HSA-3266540] MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182412] Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2
maxDepth	1
modified	[InstanceEdit:9957084] Shamovsky, Veronica, 2025-06-17
name	Activation of MASPs
output	[DefinedSet:R-HSA-3266545] MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane]
precedingEvent	[Reaction:R-HSA-166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - Homo sapiens [Reaction:R-HSA-2855125] Ficolin-1 binds to molecular patterns on the target cell surface - Homo sapiens [Reaction:R-HSA-2855054] Ficolin-2 binds to molecular patterns on the target cell surface - Homo sapiens [Reaction:R-HSA-2855077] Ficolin-3 binds to molecular patterns on the target cell surface - Homo sapiens [Reaction:R-HSA-8852509] CL-LK binds carbohydrates on target cell surface - Homo sapiens [Reaction:R-HSA-9957161] MBL2 binds SARS-CoV-2 S - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166726
summation	[Summation:182410] MBL or ficolins binding to carbohydrates on the target surfa...
updateTrackers	[UpdateTracker:9787515] Update Tracker - [Reaction:166726] Activation of MASPs - v45:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787515] Update Tracker - [Reaction:166726] Activation of MASPs - v45:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-166662] Lectin pathway of complement activation
(precedingEvent)	[Reaction:R-HSA-166753] Conversion of C4 into C4a and C4b [Reaction:R-HSA-166792] Conversion of C2 into C2a and C2b