Reactome | nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs

Schema > Reaction > Entries

nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs Show undefined attributes

authored	[InstanceEdit:9815360] Stephan, Ralf, 2022-08-17
catalystActivity	[CatalystActivity:9792634] mRNA guanylyltransferase activity of pp1ab-nsp12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9815530] Stephan, Ralf, 2022-08-18
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9815529
disease	[Disease:9683912] COVID-19
displayName	nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs
edited	[InstanceEdit:9815360] Stephan, Ralf, 2022-08-17
eventOf	[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9694476] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs - Homo sapiens [Reaction:R-HSA-9694632] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-COV-9713653] SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9792626] The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme [LiteratureReference:9713187] Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs
output	[Complex:R-COV-9792635] GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9694506] Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773795] Gillespie, Marc E, 2022-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9815529
summation	[Summation:9792653] Capping of viral mRNA starts with the transfer of a guanylyl...

Referrals

(hasEvent)	[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs
(precedingEvent)	[BlackBoxEvent:R-HSA-9694476] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs [Reaction:R-HSA-9694632] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA

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