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Schema
>
Reaction
>
Entries
C-ter TLR7 dimer binds TLR7, TLR8 ligands
Show undefined attributes
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authored
[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
category
binding
compartment
[Compartment:74700] endosome membrane
[Compartment:171907] endosome lumen
created
[InstanceEdit:168000] Gillespie, ME, 2005-11-10 16:24:09
dbId
167983
displayName
C-ter TLR7 dimer binds TLR7, TLR8 ligands
edited
[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf
[Pathway:R-HSA-9692916] SARS-CoV-1 activates/modulates innate immune responses - Homo sapiens
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Homo sapiens
followingEvent
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 - Homo sapiens
input
[Complex:R-HSA-1679575] C-ter TLR7 dimer [endosome membrane]
[DefinedSet:R-NUL-9684904] TLR7, TLR8 ligands [endosome lumen]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:188148] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
[LiteratureReference:188144] Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
[LiteratureReference:188142] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
[LiteratureReference:188159] Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
[LiteratureReference:9684933] Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
C-ter TLR7 dimer binds TLR7, TLR8 ligands
output
[Complex:R-HSA-188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane]
regulatedBy
[NegativeRegulation:9691206] Negative regulation by 'C-ter TLR7 dimer:HCQ [endosome membrane]'
regulationReference
[RegulationReference:9691205] Negative regulation by 'C-ter TLR7 dimer:HCQ [endosome membrane]' Novel and Selective TLR7 Antagonists among the Imidazo[1,2-
a
]pyrazines, Imidazo[1,5-
a
]quinoxalines, and Pyrazolo[1,5-
a
]quinoxalines Series
relatedSpecies
[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-167983
summation
[Summation:188745] Endosomal recognition of viral single stranded (ss) RNA occu...
Referrals
(hasEvent)
[Pathway:R-HSA-9692916] SARS-CoV-1 activates/modulates innate immune responses
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
(precedingEvent)
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9
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