Reactome | M protein oligomerization

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M protein oligomerization Show undefined attributes

authored	[InstanceEdit:9696947] Rothfels, Karen, 2020-07-30
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694487
disease	[Disease:9683912] COVID-19
displayName	M protein oligomerization
edited	[InstanceEdit:9696947] Rothfels, Karen, 2020-07-30
eventOf	[Pathway:R-HSA-9694322] Virion Assembly and Release - Homo sapiens
followingEvent	[Reaction:R-HSA-9694444] E and N are recruited to the M lattice - Homo sapiens
inferredFrom	[Reaction:R-HSA-9684218] M protein oligomerization - Homo sapiens
input	600 × [EntityWithAccessionedSequence:R-COV-9694439] M [endoplasmic reticulum-Golgi intermediate compartment membrane] 600 × [EntityWithAccessionedSequence:R-COV-9694446] N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9678159] Self-assembly of severe acute respiratory syndrome coronavirus membrane protein [LiteratureReference:9684152] Coronavirus particle assembly: primary structure requirements of the membrane protein [LiteratureReference:9684149] Assembly of the coronavirus envelope: homotypic interactions between the M proteins [LiteratureReference:9684179] Oligomerization of a trans-Golgi/trans-Golgi network retained protein occurs in the Golgi complex and may be part of its retention [LiteratureReference:9680341] The molecular biology of coronaviruses [LiteratureReference:9682998] Characterization of severe acute respiratory syndrome coronavirus membrane protein [LiteratureReference:9683029] Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein [LiteratureReference:9684137] Assembly of human severe acute respiratory syndrome coronavirus-like particles [LiteratureReference:9684168] Generation of synthetic severe acute respiratory syndrome coronavirus pseudoparticles: implications for assembly and vaccine production [LiteratureReference:9684163] Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system [LiteratureReference:9684142] Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent [LiteratureReference:9684187] The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [LiteratureReference:9684155] Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus [LiteratureReference:9684174] Identifying SARS-CoV membrane protein amino acid residues linked to virus-like particle assembly
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	M protein oligomerization
output	[Complex:R-COV-9694371] M lattice [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9694367] Glycosylated M localizes to the Golgi membrane - Homo sapiens [BlackBoxEvent:R-HSA-9694555] Protein M localizes to the Golgi membrane - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694487
summation	[Summation:9694283] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. Despite its importance, expression of M alone is not sufficient to drive formation of a mature virus (reviewed in Masters, 2006). Protein-protein interactions between M and S, N and E, among other components, are required for assembly of a mature virus and for membrane curvature. Many studies have examined the minimal system required for release of viral like particles (VLPs) with sometimes contradictory results, but interactions between M, N and E are sufficient to promote release of significant numbers of VLPs (Ho et al, 2004; Huang et al, 2004; Mortola and Roy, 2004; Hsieh et al, 2005; Siu et al, 2008; Hatakeyama et al, 2008; Tseng et al, 2013; reviewed in Masters, 2006)

Referrals

(hasEvent)	[Pathway:R-HSA-9694322] Virion Assembly and Release
(precedingEvent)	[Reaction:R-HSA-9694444] E and N are recruited to the M lattice
(inferredTo)	[Reaction:R-HSA-9684218] M protein oligomerization

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