Reactome | TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9

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TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975111
displayName	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
followingEvent	[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - Homo sapiens [Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens
input	[Complex:R-HSA-975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] 4 × [EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB [LiteratureReference:446876] TRAF6 is a signal transducer for interleukin-1 [LiteratureReference:165903] Identification of threonine 66 as a functionally critical residue of the [LiteratureReference:450151] Distinct molecular mechanism for initiating TRAF6 signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
orthologousEvent	[Reaction:R-GGA-532632] TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 - Gallus gallus
output	[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens [Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975111
summation	[Summation:446863] Hyperphosphorylated IRAK1, still within the receptor complex... [Summation:937037] IRAK-2 has two TRAF6 binding motifs that are responsible for...
updateTrackers	[UpdateTracker:9788617] Update Tracker - [Reaction:975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788617] Update Tracker - [Reaction:975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - v41:[modifyText]
(hasEvent)	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
(precedingEvent)	[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex [Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation