Reactome | Nsp3:nsp4 binds to nsp6

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Nsp3:nsp4 binds to nsp6 Show undefined attributes

authored	[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12
category	uncertain
compartment	[Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694630
disease	[Disease:9683912] COVID-19
displayName	Nsp3:nsp4 binds to nsp6
edited	[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
eventOf	[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9694576] nsp3 binds to nsp7-8 and nsp12-16 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6 - Homo sapiens
input	[Complex:R-COV-9694366] nsp3:nsp4 [double membrane vesicle viral factory outer membrane] [DefinedSet:R-COV-9694770] nsp6 [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nsp3:nsp4 binds to nsp6
output	[Complex:R-COV-9694728] nsp3:nsp4:nsp6 [double membrane vesicle viral factory outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9694630
summation	[Summation:9694437] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. The SARS-CoV nsp3 was shown to bind ORF7a and Nsp6 by using proteomics analysis (Neuman et al, 2008)

Referrals

(hasEvent)	[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
(precedingEvent)	[BlackBoxEvent:R-HSA-9694576] nsp3 binds to nsp7-8 and nsp12-16
(inferredTo)	[BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6

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