Reactome | IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]

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IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] Show undefined attributes

catalystActivities	[CatalystActivity:975176] ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex - Homo sapiens [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation - Homo sapiens
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975131
displayName	IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
hasComponent	4 × [EntityWithAccessionedSequence:R-HSA-450274] IRF7 [endosome membrane] [Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:975069] Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling [LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
maxDepth	10
modified	[InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
name	IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9
producedByEvent	[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-975131
updateTrackers	[UpdateTracker:9954017] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v93:[updateContainedComponent] [UpdateTracker:9870234] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9870918] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870038] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v36:[updateContainedComponent] [UpdateTracker:9872929] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9901591] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v74:[updateContainedComponent] [UpdateTracker:9901239] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v73:[updateContainedComponent] [UpdateTracker:9903176] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v80:[updateContainedComponent] [UpdateTracker:9902947] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v79:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9954017] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v93:[updateContainedComponent] [UpdateTracker:9870234] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9870918] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870038] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v36:[updateContainedComponent] [UpdateTracker:9872929] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9901591] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v74:[updateContainedComponent] [UpdateTracker:9901239] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v73:[updateContainedComponent] [UpdateTracker:9903176] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v80:[updateContainedComponent] [UpdateTracker:9902947] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v79:[updateContainedComponent]
(input)	[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
(physicalEntity)	[CatalystActivity:975176] ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
(output)	[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation

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