Reactome | SARS-CoV-2 8 binds class I MHC

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SARS-CoV-2 8 binds class I MHC Show undefined attributes

authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
category	binding
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:5263265] lumenal side of endoplasmic reticulum membrane
created	[InstanceEdit:9755396] Shamovsky, Veronica, 2021-10-08
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9755328
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 8 binds class I MHC
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
followingEvent	[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1 - Homo sapiens
input	[Complex:R-COV-9755345] 8 homodimer [endoplasmic reticulum lumen] [Complex:R-HSA-983114] Antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9755378] The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-?
maxDepth	1
modified	[InstanceEdit:9910706] D'Eustachio, Peter, 2024-05-16
name	SARS-CoV-2 8 binds class I MHC
output	[Complex:R-HSA-9755340] 8:antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-983138] Transport of MHC heterotrimer to ER exit site - Homo sapiens [Reaction:R-HSA-9755354] 8 forms a homodimer - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9755328
summation	[Summation:9755411] During viral infection, T cells recognize the viral antigens...

Referrals

(hasEvent)	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses
(precedingEvent)	[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1

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