Reactome | Spike protein gets palmitoylated

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Spike protein gets palmitoylated Show undefined attributes

authored	[InstanceEdit:9696918] Stephan, Ralf, 2020-07-22
catalystActivity	[CatalystActivity:9766354] protein-cysteine S-palmitoyltransferase activity of Palmitoyltransferases [Golgi membrane]
category	transition
compartment	[Compartment:190626] endoplasmic reticulum-Golgi intermediate compartment
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694341
disease	[Disease:9683912] COVID-19
displayName	Spike protein gets palmitoylated
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694548] Maturation of spike protein - Homo sapiens
followingEvent	[Reaction:R-HSA-9694467] Spike protein forms a homotrimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-COV-9766369] high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] [SimpleEntity:R-ALL-9766371] palmitoyl-CoA [endoplasmic reticulum-Golgi intermediate compartment]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9733305] Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects [LiteratureReference:9766357] Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity [URL:9766359] https://doi.org/10.1101/2020.12.20.423603 [LiteratureReference:9766378] Palmitoylation of SARS-CoV-2 S protein is critical for S-mediated syncytia formation and virus entry [LiteratureReference:9766399] S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity [LiteratureReference:9766383] S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity [LiteratureReference:9766385] The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Spike protein gets palmitoylated
output	[SimpleEntity:R-ALL-9766372] CoA-SH [endoplasmic reticulum-Golgi intermediate compartment] [EntityWithAccessionedSequence:R-COV-9696943] high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
precedingEvent	[BlackBoxEvent:R-HSA-9694780] Spike translocates to ERGIC - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
revised	[InstanceEdit:9733306] Stephan, Ralf, 2021-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694341
summation	[Summation:9694759] Palmitoylation of SARS-CoV-2 Spike can occur on multiple dif...
updateTrackers	[UpdateTracker:9775114] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v80:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9775494] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v78:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775114] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v80:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9775494] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v78:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9694548] Maturation of spike protein
(precedingEvent)	[Reaction:R-HSA-9694467] Spike protein forms a homotrimer

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