Reactome | 3CLp cleaves pp1a

authored	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
catalystActivity	[CatalystActivity:9694394] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694441
disease	[Disease:9683912] COVID-19
displayName	3CLp cleaves pp1a
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA - Homo sapiens [Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA - Homo sapiens [Reaction:R-HSA-9694333] 3CLp forms a homodimer - Homo sapiens [Reaction:R-HSA-9694338] nsp1-4 cleaves itself - Homo sapiens [BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer - Homo sapiens [Reaction:R-HSA-9765952] nsp12 guanylates nsp7 - Homo sapiens [Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11 - Homo sapiens [Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4 - Homo sapiens [BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-COV-9681986] pp1a [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9761243] Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication [LiteratureReference:9761289] Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp cleaves pp1a
output	[EntityWithAccessionedSequence:R-COV-9681994] pp1a-3CL [cytosol] [EntityWithAccessionedSequence:R-COV-9694778] pp1a-nsp1-4 [cytosol] [EntityWithAccessionedSequence:R-COV-9694668] pp1a-nsp6-11 [cytosol]
precedingEvent	[Reaction:R-HSA-9694333] 3CLp forms a homodimer - Homo sapiens [BlackBoxEvent:R-HSA-9694334] mRNA1 is translated to pp1a - Homo sapiens
regulatedBy	[NegativeRegulation:9694290] Negative regulation by '3CLp dimer:3CLp inhibitors [cytosol]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694441
summation	[Summation:9694751] Main protease of SARS-CoV-2 (3CLpro, nsp5) cleaves all cleav...
updateTrackers	[UpdateTracker:9774999] Update Tracker - [Reaction:9694441] 3CLp cleaves pp1a - v80:[add_removeLiteratureReference, modifyText]

(updatedInstance)	[UpdateTracker:9774999] Update Tracker - [Reaction:9694441] 3CLp cleaves pp1a - v80:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9694301] Maturation of replicase proteins
(precedingEvent)	[BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer [BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation [Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA [Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA [Reaction:R-HSA-9765952] nsp12 guanylates nsp7 [Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11 [Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4 [Reaction:R-HSA-9694333] 3CLp forms a homodimer [Reaction:R-HSA-9694338] nsp1-4 cleaves itself

3CLp cleaves pp1a Show undefined attributes

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