Reactome | S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion

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S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion Show undefined attributes

authored	[InstanceEdit:9770185] Stephan, Ralf, 2022-03-25
catalystActivity	[CatalystActivity:9686728] serine-type endopeptidase activity of TMPRSS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9770190] Stephan, Ralf, 2022-03-25
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9770187
disease	[Disease:9683912] COVID-19
displayName	S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
edited	[InstanceEdit:9796426] Stephan, Ralf, 2022-08-09
eventOf	[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion - Homo sapiens
input	[Complex:R-COV-9698995] S2 trimer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9770181] Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion [LiteratureReference:9733465] SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation [LiteratureReference:9733897] Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics [LiteratureReference:9733305] Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects [LiteratureReference:9761410] TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells [LiteratureReference:9733499] Syncytia formation by SARS-CoV-2-infected cells [LiteratureReference:9770280] Proteolytic activation of SARS-CoV-2 spike protein [LiteratureReference:9770287] Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia [LiteratureReference:9770285] Flagging fusion: Phosphatidylserine signaling in cell-cell fusion [LiteratureReference:9766378] Palmitoylation of SARS-CoV-2 S protein is critical for S-mediated syncytia formation and virus entry [LiteratureReference:9770316] Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
output	3 × [EntityWithAccessionedSequence:R-COV-9770188] S(686-815) [plasma membrane] 3 × [EntityWithAccessionedSequence:R-COV-9770189] Spike S2' Fragment [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2 - Homo sapiens
regulatedBy	[PositiveRegulation:9770284] Positive regulation by 'ANOs [plasma membrane]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773891] Gillespie, Marc E, 2022-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9770187
summation	[Summation:9770214] SARS-CoV-2 fusion protein (S2', FP, fusion peptide) is a pro...

Referrals

(hasEvent)

[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion