Reactome | FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis

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FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis Show undefined attributes

authored	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
catalystActivity	[CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699008] Gillespie, Marc E, 2020-09-05
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9699007
disease	[Disease:9683912] COVID-19
displayName	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
edited	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
eventOf	[Pathway:R-HSA-9694614] Attachment and Entry - Homo sapiens
followingEvent	[Reaction:R-HSA-9694689] Fusion and Release of SARS-CoV-2 Nucleocapsid - Homo sapiens
input	[Complex:R-HSA-9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699000] The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin [LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells [LiteratureReference:9681513] A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry [LiteratureReference:9761410] TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells [LiteratureReference:9765579] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis [LiteratureReference:9765590] Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation [LiteratureReference:9768875] SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems [LiteratureReference:9768894] Neuropilin-1 is a host factor for SARS-CoV-2 infection [LiteratureReference:9768909] Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity [LiteratureReference:9769490] Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 [LiteratureReference:9769474] KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney [LiteratureReference:9769548] Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
output	[EntityWithAccessionedSequence:R-HSA-9686721] glycosylated-ACE2 [endocytic vesicle membrane] [DefinedSet:R-HSA-2076618] HSPGs [plasma membrane] [Complex:R-COV-9694585] S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]
precedingEvent	[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - Homo sapiens [BlackBoxEvent:R-HSA-9736953] FURIN translocates to the plasma membrane - Homo sapiens
regulatedBy	[PositiveRegulation:9768874] Positive regulation by 'NRP1 [plasma membrane]' [PositiveRegulation:9769473] Positive regulation by 'HAVCR1 [plasma membrane]' [NegativeRegulation:9769499] Negative regulation by 'Spike:heparin [extracellular region]'
regulationReference	[RegulationReference:9768899] Positive regulation by 'NRP1 [plasma membrane]' SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems [RegulationReference:9769489] Positive regulation by 'HAVCR1 [plasma membrane]' KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney [RegulationReference:9769496] Negative regulation by 'Spike:heparin [extracellular region]' The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9699007
summation	[Summation:9699005] In a SARS-CoV-2 infection the cellular protease furin cleave...
updateTrackers	[UpdateTracker:9776134] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v77:[modifyText] [UpdateTracker:9774759] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v81:[addLiteratureReference, addRegulator, add_removeOutput, modifyText] [UpdateTracker:9774944] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v80:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776134] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v77:[modifyText] [UpdateTracker:9774759] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v81:[addLiteratureReference, addRegulator, add_removeOutput, modifyText] [UpdateTracker:9774944] Update Tracker - [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - v80:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9694614] Attachment and Entry
(precedingEvent)	[Reaction:R-HSA-9694689] Fusion and Release of SARS-CoV-2 Nucleocapsid

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