Reactome | 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]

Schema > Complex > Entries

compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9755396] Shamovsky, Veronica, 2021-10-08
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9755322
disease	[Disease:9683912] COVID-19
displayName	8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]
hasComponent	[Complex:R-HSA-9755340] 8:antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] [Complex:R-HSA-5683379] Beclin-1 complex [endoplasmic reticulum membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:5263265] lumenal side of endoplasmic reticulum membrane
isChimeric	false
literatureReference	[LiteratureReference:9755378] The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-?
maxDepth	6
name	8:class I MHC:BECN1 complex ATG14:PIK3C3:PIK3R4:BECN1:8:class I MHC:B2M:antigen peptide
negativelyRegulates	[NegativeRegulation:9765924] Negative regulation by '8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]'
producedByEvent	[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1 - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9755322
updateTrackers	[UpdateTracker:9905015] Update Tracker - [Complex:9755322] 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] - v84:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9905015] Update Tracker - [Complex:9755322] 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] - v84:[updateContainedComponent]
(regulator)	[NegativeRegulation:9765924] Negative regulation by '8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]'
(output)	[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1

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