Reactome | IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9

Schema > Reaction > Entries

IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:975169] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
catalystActivityReference	[CatalystActivityReference:9643573] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] IRAK-4: a novel member of the IRAK family with the properties of an
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975170
displayName	IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
followingEvent	[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:446630] Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop [LiteratureReference:937035] Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
orthologousEvent	[Reaction:R-GGA-571316] Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. - Gallus gallus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
precedingEvent	[Reaction:R-HSA-975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975170
summation	[Summation:446631] IRAK4 is activated by autophosphorylation at 3 positions wit...

Referrals

(hasEvent)	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
(precedingEvent)	[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.

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