Reactome | mRNA1 is translated to pp1ab

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mRNA1 is translated to pp1ab Show undefined attributes

authored	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694274
disease	[Disease:9683912] COVID-19
displayName	mRNA1 is translated to pp1ab
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694676] Translation of Replicase and Assembly of the Replication Transcription Complex - Homo sapiens
followingEvent	[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens [Reaction:R-HSA-9694732] 3CLp cleaves pp1ab - Homo sapiens
inferredFrom	[BlackBoxEvent:R-HSA-9684277] mRNA1 is translated to pp1ab - Homo sapiens
input	[EntityWithAccessionedSequence:R-COV-9694393] m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9684329] Programmed ribosomal frameshifting in decoding the SARS-CoV genome
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	mRNA1 is translated to pp1ab
negativePrecedingEvent	[NegativePrecedingEvent:9763946] Futile Cycle: RTC completes synthesis of the minus strand genomic RNA complement
output	[EntityWithAccessionedSequence:R-COV-9682068] pp1ab [cytosol]
precedingEvent	[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome - Homo sapiens [BlackBoxEvent:R-HSA-9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9694274
summation	[Summation:9694422] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. In about 15% of translation attempts of the genomic viral mRNA1 in the host cell cytosol, a -1 frameshift happens after the nsp10 gene that leads to translation of the full pp1ab polyprotein (Baranov et al, 2005).

Referrals

(precedingEvent)	[Pathway:R-HSA-9694301] Maturation of replicase proteins [Reaction:R-HSA-9694732] 3CLp cleaves pp1ab
(hasEvent)	[Pathway:R-HSA-9694676] Translation of Replicase and Assembly of the Replication Transcription Complex
(inferredTo)	[BlackBoxEvent:R-HSA-9684277] mRNA1 is translated to pp1ab