Reactome | SARS-CoV-2 nsp3 deISGylates ISGylated IRF3

Schema > Reaction > Entries

SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 Show undefined attributes

authored	[InstanceEdit:9733900] Stephan, Ralf, 2021-06-11
catalystActivity	[CatalystActivity:9729742] ISG15-specific peptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9729725
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
followingEvent	[Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-1169389] ISGylated IRF3 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9705666] Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity [LiteratureReference:9729745] Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease [LiteratureReference:9729708] Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling [LiteratureReference:9762486] Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
output	[EntityWithAccessionedSequence:R-HSA-166251] IRF3 [cytosol] [EntityWithAccessionedSequence:R-HSA-936552] ISG15 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9694389] nsp3 is glycosylated - Homo sapiens [Reaction:R-HSA-1169394] ISGylation of IRF3 - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9729725
summation	[Summation:9729739] The endopeptidase activity of SARS-CoV-2 nsp3 (PLpro) includ...

Referrals

(hasEvent)	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses
(precedingEvent)	[Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3

Cite Us!