Reactome | Unknown kinase phosphorylates nucleoprotein

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Unknown kinase phosphorylates nucleoprotein Show undefined attributes

authored	[InstanceEdit:9728847] Stephan, Ralf, 2021-04-22
catalystActivity	[CatalystActivity:9767993] protein serine/threonine kinase activity of unknown kinase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729337] Stephan, Ralf, 2021-04-28
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9729300
disease	[Disease:9683912] COVID-19
displayName	Unknown kinase phosphorylates nucleoprotein
edited	[InstanceEdit:9730587] Stephan, Ralf, 2021-05-10
eventOf	[Pathway:R-HSA-9694631] Maturation of nucleoprotein - Homo sapiens
followingEvent	[Reaction:R-HSA-9729283] Nucleoprotein is methylated by PRMT1 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-COV-9729277] p-8S,2T-N [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9729344] The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro [LiteratureReference:9729331] The Global Phosphorylation Landscape of SARS-CoV-2 Infection [LiteratureReference:9729273] Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein [LiteratureReference:9729276] Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Unknown kinase phosphorylates nucleoprotein Phosphorylation of nucleoprotein
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [EntityWithAccessionedSequence:R-COV-9729264] p-11S,2T-N [cytosol]
precedingEvent	[Reaction:R-HSA-9729318] CSNK1A1 phosphorylates nucleoprotein - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9730585] Acencio, Marcio Luis, 2021-05-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9729300
summation	[Summation:9729304] Most of SARS-Cov-2 nucleocapsid phosphorylations in its S/R-...
updateTrackers	[UpdateTracker:9774932] Update Tracker - [Reaction:9729300] Unknown kinase phosphorylates nucleoprotein - v80:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9774932] Update Tracker - [Reaction:9729300] Unknown kinase phosphorylates nucleoprotein - v80:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-9694631] Maturation of nucleoprotein
(precedingEvent)	[Reaction:R-HSA-9729283] Nucleoprotein is methylated by PRMT1

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