Reactome | ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA

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ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA Show undefined attributes

authored	[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694677
disease	[Disease:9683912] COVID-19
displayName	ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA
edited	[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
eventOf	[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome - Homo sapiens
inferredFrom	[Reaction:R-HSA-9682009] ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA - Homo sapiens
input	[EntityWithAccessionedSequence:R-COV-9694393] m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol] [EntityWithAccessionedSequence:R-HSA-9682010] ZCRB1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9680316] Binding of the 5'-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcription
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA
negativePrecedingEvent	[NegativePrecedingEvent:9763949] Futile Cycle: RTC completes synthesis of the minus strand genomic RNA complement
output	[Complex:R-HSA-9698376] ZCRB1:m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
precedingEvent	[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome - Homo sapiens [BlackBoxEvent:R-HSA-9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694677
summation	[Summation:9694666] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. Human zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1, also known as MADP1) binds to the 5'UTR of the plus strand genomic RNA of the SARS-CoV-1, as well as other coronaviruses, infectious bronchitis virus (IBV) and human coronavirus OC43. ZCRB1 normally localizes to the nucleus, where it is a component of the U12-type spliceosome. Upon infection with a coronavirus, ZCRB1 appears in the cytosol. Binding of ZCRB1 to the 5'UTR stem of coronavirus genomic RNA is thought to be necessary for efficient transcription of viral genes (Tan et al. 2012).

Referrals

(hasEvent)	[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome
(inferredTo)	[Reaction:R-HSA-9682009] ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA