Reactome | 3a localizes to the cell membrane

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3a localizes to the cell membrane Show undefined attributes

authored	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
category	uncertain
compartment	[Compartment:190626] endoplasmic reticulum-Golgi intermediate compartment [Compartment:876] plasma membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
dbId	9694572
disease	[Disease:9683912] COVID-19
displayName	3a localizes to the cell membrane
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694719] Maturation of protein 3a - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9694727] Endocytosis of protein 3a - Homo sapiens [Reaction:R-HSA-9730521] SARS-CoV-2 3a induces potassium efflux - Homo sapiens [BlackBoxEvent:R-HSA-9694308] 3a is externalized together with membrane structures - Homo sapiens
input	[Complex:R-COV-9694598] O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9730532] SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway [LiteratureReference:9682779] A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3a localizes to the cell membrane
output	[Complex:R-COV-9694306] O-glycosyl 3a tetramer [plasma membrane]
precedingEvent	[Reaction:R-HSA-9694718] O-glycosylation of 3a is terminated - Homo sapiens [BlackBoxEvent:R-HSA-9694308] 3a is externalized together with membrane structures - Homo sapiens [Reaction:R-HSA-9694662] Protein 3a forms a homotetramer - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9694572
summation	[Summation:9694296] Coronavirus viroporins (3a) contain cargo sorting motifs in ...

Referrals

(hasEvent)	[Pathway:R-HSA-9694719] Maturation of protein 3a
(precedingEvent)	[BlackBoxEvent:R-HSA-9694727] Endocytosis of protein 3a [Reaction:R-HSA-9730521] SARS-CoV-2 3a induces potassium efflux [BlackBoxEvent:R-HSA-9694308] 3a is externalized together with membrane structures