Reactome | Nucleoprotein translocates to the ERGIC outer membrane

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Nucleoprotein translocates to the ERGIC outer membrane Show undefined attributes

authored	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694568
disease	[Disease:9683912] COVID-19
displayName	Nucleoprotein translocates to the ERGIC outer membrane
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28 [InstanceEdit:9730604] Stephan, Ralf, 2021-05-10
eventOf	[Pathway:R-HSA-9694631] Maturation of nucleoprotein - Homo sapiens
followingEvent	[Reaction:R-HSA-9694455] SUMO-p-N protein dimer binds genomic RNA - Homo sapiens [Reaction:R-HSA-9694281] Encapsidation of SARS coronavirus genomic RNA - Homo sapiens
inferredFrom	[BlackBoxEvent:R-HSA-9683765] Nucleoprotein translocates to the ERGIC outer membrane - Homo sapiens
input	[Complex:R-COV-9694702] N dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9682915] The intracellular sites of early replication and budding of SARS-coronavirus
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nucleoprotein translocates to the ERGIC outer membrane
negativePrecedingEvent	[NegativePrecedingEvent:9763803] Futile Cycle: Uncoating of SARS-CoV-2 Genome
output	[Complex:R-COV-9694573] N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-9694363] Dimerisation of nucleoprotein - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9694568
summation	[Summation:9694626] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. As early as 3 hours post-infection, cytoplasmic accumulations of N are formed in infected cells, they colocalize with viral RNA. From 5 hours post-infection on, N can be detected in the Golgi, the budding site (Stertz et al, 2007)

Referrals

(hasEvent)	[Pathway:R-HSA-9694631] Maturation of nucleoprotein
(precedingEvent)	[Reaction:R-HSA-9694281] Encapsidation of SARS coronavirus genomic RNA [Reaction:R-HSA-9694455] SUMO-p-N protein dimer binds genomic RNA
(inferredTo)	[BlackBoxEvent:R-HSA-9683765] Nucleoprotein translocates to the ERGIC outer membrane

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