Reactome | 3CLp dimer binds 3CLp inhibitors

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3CLp dimer binds 3CLp inhibitors Show undefined attributes

authored	[InstanceEdit:9681587] Jassal, Bijay, 2020-04-02
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694592
definition	Inhibition
disease	[Disease:9683912] COVID-19
displayName	3CLp dimer binds 3CLp inhibitors
edited	[InstanceEdit:9681587] Jassal, Bijay, 2020-04-02 [InstanceEdit:9732920] Stephan, Ralf, 2021-05-28
eventOf	[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens
input	[Complex:R-COV-9694407] 3CLp dimer [cytosol] [DefinedSet:R-ALL-9731705] 3CLp inhibitors [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9681590] ?-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment [LiteratureReference:9686168] Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations [LiteratureReference:9762564] Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection [LiteratureReference:9731715] Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease [LiteratureReference:9731677] Structure of M^pro from SARS-CoV-2 and discovery of its inhibitors [LiteratureReference:9762561] Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir [URL:9732768] https://doi.org/10.21203/RS.3.RS-26344/V1 [LiteratureReference:9733028] Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry [LiteratureReference:9732886] Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening [LiteratureReference:9732977] Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients [LiteratureReference:9732939] Malleability of the SARS-CoV-2 3CL M^pro Active-Site Cavity Facilitates Binding of Clinical Antivirals [LiteratureReference:9732960] Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture [LiteratureReference:9732912] Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection [LiteratureReference:9732794] The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections [LiteratureReference:9758159] An oral SARS-CoV-2 M^pro inhibitor clinical candidate for the treatment of COVID-19
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp dimer binds 3CLp inhibitors 3C-like proteinase dimer binds 3CLp inhibitors
output	[Complex:R-COV-9694375] 3CLp dimer:3CLp inhibitors [cytosol]
precedingEvent	[Reaction:R-HSA-9694333] 3CLp forms a homodimer - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9694592
summation	[Summation:9694263] The rep proteases that are essential for viral polyprotein p...
updateTrackers	[UpdateTracker:9775296] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v79:[addLiteratureReference, modifyText] [UpdateTracker:9775203] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v80:[add_removeLiteratureReference] [UpdateTracker:9775566] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v78:[addLiteratureReference, add_removeInput, modifyText] [UpdateTracker:9774710] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v81:[modifyText] [UpdateTracker:9776124] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v77:[addLiteratureReference, modifyText]

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[UpdateTracker:9775296] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v79:[addLiteratureReference, modifyText]
[UpdateTracker:9775203] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v80:[add_removeLiteratureReference]
[UpdateTracker:9775566] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v78:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9774710] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v81:[modifyText]
[UpdateTracker:9776124] Update Tracker - [BlackBoxEvent:9694592] 3CLp dimer binds 3CLp inhibitors - v77:[addLiteratureReference, modifyText]

(hasEvent)

[Pathway:R-HSA-9694301] Maturation of replicase proteins

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