Reactome | SARS-CoV-2 N binds to G3BP1,G3BP2

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SARS-CoV-2 N binds to G3BP1,G3BP2 Show undefined attributes

authored	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729515] Stephan, Ralf, 2021-04-28
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9729481
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 N binds to G3BP1,G3BP2
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
input	[DefinedSet:R-HSA-9729488] G3BP1,G3BP2 [cytosol] [Complex:R-COV-9694702] N dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[URL:9729496] https://doi.org/10.1101/2020.10.23.342113 [LiteratureReference:9705013] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing [LiteratureReference:9729494] SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production [LiteratureReference:9729506] SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation into stress granules through its N-terminal intrinsically disordered region [LiteratureReference:9755717] Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 N binds to G3BP1,G3BP2
output	[Complex:R-HSA-9729513] G3BP1,G3BP2:N [cytosol]
precedingEvent	[Reaction:R-HSA-9694363] Dimerisation of nucleoprotein - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9729481
summation	[Summation:9729477] Stress granules (SGs) are dynamic large cytoplasmic mRNA-pro...

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[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses

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