Reactome | SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors

Schema > Reaction > Entries

SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors Show undefined attributes

authored	[InstanceEdit:9697108] Jassal, Bijay, 2020-08-06
category	binding
compartment	[Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694665
definition	Inhibition
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors
edited	[InstanceEdit:9697108] Jassal, Bijay, 2020-08-06
eventOf	[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome - Homo sapiens
input	[DefinedSet:R-ALL-9687408] RTC inhibitors [double membrane vesicle viral factory outer membrane] [Complex:R-COV-9694618] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9680274] Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase [LiteratureReference:9680275] Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease [LiteratureReference:9680461] The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus [LiteratureReference:9684014] Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses [LiteratureReference:9682443] An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice [LiteratureReference:9682430] Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia [LiteratureReference:9689384] Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors
output	[Complex:R-COV-9694327] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9694605] nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement - Homo sapiens [Reaction:R-HSA-9694632] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09 [InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694665
summation	[Summation:9697106] Remdesivir (GS-5734) is an investigational nucleotide analog...
updateTrackers	[UpdateTracker:9774954] Update Tracker - [Reaction:9694665] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors - v80:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9774954] Update Tracker - [Reaction:9694665] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors - v80:[modifyText]
(hasEvent)	[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome