Reactome | nsp12 binds nsp7 and nsp8

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nsp12 binds nsp7 and nsp8 Show undefined attributes

authored	[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12 [InstanceEdit:9697675] Senff-Ribeiro, Andrea, 2020-08-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9691362] Orlic-Milacic, Marija, 2020-06-11
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9691363
disease	[Disease:9683912] COVID-19
displayName	nsp12 binds nsp7 and nsp8
edited	[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
eventOf	[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) - Homo sapiens
followingEvent	[Reaction:R-HSA-9694304] nsp14 binds nsp12 - Homo sapiens
input	[Complex:R-COV-9771682] nsp12:2Fe4S4 [cytosol] [Complex:R-COV-9691348] nsp7:nsp8 [cytosol] [DefinedSet:R-COV-9691351] nsp8 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9691337] Structure of the RNA-dependent RNA polymerase from COVID-19 virus [LiteratureReference:9696799] Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis [LiteratureReference:9697109] Structure of replicating SARS-CoV-2 polymerase [LiteratureReference:9697280] Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir [LiteratureReference:9713180] Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 [LiteratureReference:9762518] Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP [LiteratureReference:9762524] Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp12 binds nsp7 and nsp8
output	[Complex:R-COV-9691364] nsp7:nsp8:nsp12 [cytosol]
precedingEvent	[Reaction:R-HSA-9691335] nsp7 binds nsp8 - Homo sapiens [Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11 - Homo sapiens [BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9691363
summation	[Summation:9691361] The nsp7:nsp8 heterodimer binds to the RNA-directed RNA poly...
updateTrackers	[UpdateTracker:9774669] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v81:[add_removeInput] [UpdateTracker:9774945] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v80:[addLiteratureReference, modifyText] [UpdateTracker:9776457] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v76:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9774669] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v81:[add_removeInput] [UpdateTracker:9774945] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v80:[addLiteratureReference, modifyText] [UpdateTracker:9776457] Update Tracker - [Reaction:9691363] nsp12 binds nsp7 and nsp8 - v76:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
(precedingEvent)	[Reaction:R-HSA-9694304] nsp14 binds nsp12

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