Reactome | pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:975129] protein serine/threonine kinase activity of pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975161
displayName	pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]
hasComponent	[Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] 4 × [EntityWithAccessionedSequence:R-HSA-975117] p-T209,T387-IRAK1 [endosome membrane]
inDisease	false
literatureReference	[LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
modified	[InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
name	pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex
producedByEvent	[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-975161

(output)	[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
(input)	[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
(physicalEntity)	[CatalystActivity:975129] protein serine/threonine kinase activity of pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]