Reactome | 3CLp forms a homodimer

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3CLp forms a homodimer Show undefined attributes

authored	[InstanceEdit:9696945] Stephan, Ralf, 2020-07-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694333
disease	[Disease:9683912] COVID-19
displayName	3CLp forms a homodimer
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
eventOf	[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9694592] 3CLp dimer binds 3CLp inhibitors - Homo sapiens [Reaction:R-HSA-9729704] SARS-CoV-2 3CLpro dimer cleaves TAB1 - Homo sapiens [Reaction:R-HSA-9729741] SARS-CoV-2 3CLpro dimer cleaves NLRP12 - Homo sapiens [Reaction:R-HSA-9730501] SARS-CoV-2 3CLpro dimer binds to STING - Homo sapiens [Reaction:R-HSA-9694441] 3CLp cleaves pp1a - Homo sapiens [Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11 - Homo sapiens [Reaction:R-HSA-9694732] 3CLp cleaves pp1ab - Homo sapiens
input	2 × [DefinedSet:R-COV-9694748] nsp5 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9696988] Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved ?-ketoamide inhibitors [LiteratureReference:9762499] Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp forms a homodimer
output	[Complex:R-COV-9694407] 3CLp dimer [cytosol]
precedingEvent	[Reaction:R-HSA-9694441] 3CLp cleaves pp1a - Homo sapiens [Reaction:R-HSA-9694732] 3CLp cleaves pp1ab - Homo sapiens [Reaction:R-HSA-9694377] pp1a cleaves itself - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9694333
summation	[Summation:9694707] SARS-Cov-2 main protease forms a tight dimer. Dimerization ...
updateTrackers	[UpdateTracker:9774966] Update Tracker - [Reaction:9694333] 3CLp forms a homodimer - v80:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9774966] Update Tracker - [Reaction:9694333] 3CLp forms a homodimer - v80:[addLiteratureReference, modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9694592] 3CLp dimer binds 3CLp inhibitors [Reaction:R-HSA-9729704] SARS-CoV-2 3CLpro dimer cleaves TAB1 [Reaction:R-HSA-9729741] SARS-CoV-2 3CLpro dimer cleaves NLRP12 [Reaction:R-HSA-9730501] SARS-CoV-2 3CLpro dimer binds to STING [Reaction:R-HSA-9694441] 3CLp cleaves pp1a [Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11 [Reaction:R-HSA-9694732] 3CLp cleaves pp1ab
(hasEvent)	[Pathway:R-HSA-9694301] Maturation of replicase proteins