Reactome | TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex

Schema > BlackBoxEvent > Entries

TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
catalystActivity	[CatalystActivity:975176] ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
catalystActivityReference	[CatalystActivityReference:9643751] ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975118
displayName	TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens
input	[Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] 4 × [Polymer:R-HSA-450152] K63polyUb [cytosol] [Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 [LiteratureReference:500618] TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
output	[Complex:R-HSA-975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] [Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-975118
summation	[Summation:975096] TRAF6 E3 ubiquitin ligase activity was shown to be essential...

Referrals

(hasEvent)

[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling