Reactome | MPP5 binds SARS-CoV-2 E pentamer

Schema > Reaction > Entries

MPP5 binds SARS-CoV-2 E pentamer Show undefined attributes

authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9705656] Shamovsky, Veronica, 2020-10-28
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9705681
disease	[Disease:9683912] COVID-19
displayName	MPP5 binds SARS-CoV-2 E pentamer
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction - Homo sapiens
inferredFrom	[Reaction:R-HSA-9689608] MPP5 binds SARS-CoV-1 E pentamer - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9689606] MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Complex:R-COV-9698418] Ub-3xPalmC-E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9696717] The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis [LiteratureReference:9704980] Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein [LiteratureReference:9704978] Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis [LiteratureReference:9754606] Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MPP5 binds SARS-CoV-2 E pentamer
output	[Complex:R-HSA-9705682] MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9694294] E pentamer is transported to the Golgi - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705681
summation	[Summation:9705685] This SARS-CoV-2 event was manually inferred from the interac...

Referrals

(hasEvent)	[Pathway:R-HSA-9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction
(inferredTo)	[Reaction:R-HSA-9689608] MPP5 binds SARS-CoV-1 E pentamer