Reactome | S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]

Schema > Complex > Entries

S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
consumedByEvent	[Reaction:R-HSA-9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - Homo sapiens [Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion - Homo sapiens [BlackBoxEvent:R-HSA-9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - Homo sapiens [Reaction:R-HSA-9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis - Homo sapiens
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694785
disease	[Disease:9683912] COVID-19
displayName	S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-HSA-9683480] glycosylated-ACE2 [plasma membrane] [DefinedSet:R-HSA-2076618] HSPGs [plasma membrane] [Complex:R-COV-9694500] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
inDisease	true
includedLocation	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane [Compartment:876] plasma membrane [Compartment:830] viral capsid [Compartment:259388] virion membrane
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9767449] Stephan, Ralf, 2022-02-27
name	S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs
producedByEvent	[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9694785
summation	[Summation:9694775] This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
updateTrackers	[UpdateTracker:9902321] Update Tracker - [Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] - v77:[updateContainedComponent] [UpdateTracker:9903547] Update Tracker - [Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] - v80:[addHasComponent, modifyName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9902321] Update Tracker - [Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] - v77:[updateContainedComponent] [UpdateTracker:9903547] Update Tracker - [Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] - v80:[addHasComponent, modifyName, updateContainedComponent]
(input)	[Reaction:R-HSA-9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis [Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion [BlackBoxEvent:R-HSA-9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Reaction:R-HSA-9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
(output)	[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell